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Hand osteoarthritis in longevity populations

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Abstract

Background and aims: Previous studies have reported that centenarians escape the major agerelated diseases. No studies on prevalence and severity of osteoarthritis (OA) in longevity population have previously been reported. Because OA is associated with morbidity and mortality, we hypothesized that radiographic hand OA would generally be less prevalent and would develop at a later age in longevity populations vs non-longevity populations. Aim was to evaluate the prevalence and mode of development of radiographic hand OA in three longevity populations (Abkhazians, Azerbaijanis and Georgians) and in one non-longevity population (Russians). Methods: Cross-sectional observational study. Longevity index was calculated as a ratio of the number of individuals aged >90 years vs the number of people aged >60, expressed per mil (‰). A population with longevity index >40‰was considered as a longevity population. Radiographic hand OA was evaluated using the left hand radiograms in 14 joints according to Kellgren and Lawrence’s (K-L) grading system. Each individual was characterized by the total number of affected (K-L≥2) joints (NAJ). Prevalence of hand OA was defined as the presence of at least one affected joint. Statistical analyses included prevalence estimation, linear, logistic and polynomial regressions, and ANOVA. Results: A significant difference (p<0.003) in age standardized prevalence of hand OA was found between each pair of studied samples, except between Russians and Georgians and between Azerbaijanis and Abkhazians (p>0.05). The lowest age-standardized prevalence was found in Abkhazians, followed by Azerbaijanis and Georgians. The highest prevalence was found in Russians. ANOVA showed significant differences (p<0.01) between the age-adjusted means of NAJs. The lowest age-adjusted NAJ was found in the Abkhazian population, followed by Azerbaijanis and Georgians. The highest NAJ was found in Russians. Conclusions: We observed that the pattern of radiographic hand OA in longevity populations differs from the pattern in non-longevity populations. On average, first joints with OA appear at an older age, and progression of hand OA, measured by NAJ, is slower.

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References

  1. Lawrence RC, Felson DT, Helmick CG et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008; 58: 26–35.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Dahaghin S, Bierma-Zeinstra SM, Ginai AZ, Pols HA, Hazes JM, Koes BW. Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis 2005; 64: 682–7.

    Article  CAS  PubMed  Google Scholar 

  3. Zhang Y, Xu L, Nevitt MC et al. Lower prevalence of hand osteoarthritis among Chinese subjects in Bei**g compared with white subjects in the United States: the Bei**g Osteoarthritis Study. Arthritis Rheum 2003; 48: 1034–40.

    Article  PubMed  Google Scholar 

  4. Kalichman L, Li L, Kobyliansky E. Prevalence, pattern and determinants of radiographic hand osteoarthritis in Turkmen community- based sample. Rheumatol Int 2009; 29: 1143–9.

    Article  PubMed  Google Scholar 

  5. Hart DJ, Spector TD. Definition and epidemiology of osteoarthritis of the hand: a review. Osteoarthritis Cartilage 2000; 8 (Suppl A): S2–7.

    Article  PubMed  Google Scholar 

  6. Zhai G, Aviv A, Hunter DJ et al. Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study. Ann Rheum Dis 2006; 65: 1444–8.

    Article  CAS  PubMed  Google Scholar 

  7. Haara MM, Manninen P, Kroger H et al. Osteoarthritis of finger joints in Finns aged 30 or over: prevalence, determinants, and association with mortality. Ann Rheum Dis 2003; 62: 151–8.

    Article  CAS  PubMed  Google Scholar 

  8. Kadam UT, Jordan K, Croft PR. Clinical comorbidity in patients with osteoarthritis: a case-control study of general practice consulters in England and Wales. Ann Rheum Dis 2004; 63: 408–14.

    Article  CAS  PubMed  Google Scholar 

  9. Kalichman L, Malkin I, Livshits G, Kobyliansky E. The association between morbidity and radiographic hand osteoarthritis: a population- based study. Joint Bone Spine 2006; 73: 406–10.

    Article  PubMed  Google Scholar 

  10. Hochberg MC. Mortality in osteoarthritis. Clin Exp Rheumatol 2008; 26: S120–4.

    CAS  PubMed  Google Scholar 

  11. Ferrell RE, Salamatina NV, Dalakishvili SM, Bakuradze NA, Chakraborty R. A population genetic study in the Ochamchir region, Abkhazia, SSR. Am J Phys Anthropol 1985; 66: 63–71.

    Article  CAS  PubMed  Google Scholar 

  12. Dalakishvili S, Didebulidze N, Sumbadze T, Akuradze N, Melikadze E. Age-related changes of sex hormones level among males in populations with high index of longevity. Georgian Med News 2009; 168: 82–4.

    PubMed  Google Scholar 

  13. Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 2003; 58: 232–7.

    Article  PubMed  Google Scholar 

  14. Gondo Y, Hirose N, Arai Y et al. Functional status of centenarians in Tokyo, Japan: develo** better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci 2006; 61: 305–10.

    Article  PubMed  Google Scholar 

  15. Pavlovsky O, Kobyliansky E. Population Biology of Human Aging. Firenze, Italy, Angelo Pontecorboli Editore: 1997.

    Google Scholar 

  16. Kozlov VI, Komarova OD. Geography of longevity in the USSR (ethnic aspects). In Rubin V, Ed. First Joint US-USSR Symposium on Aging and Longevity: The First Two Years of Collaborative Effort in Abkhasia and Kentucky, vol. 1. New York: IREX 1982: 56–8.

    Google Scholar 

  17. Magnolfi SU, Petruzzi E, Pinzani P, Malentacchi F, Pazzagli M, Antonini FM. Longevity index (LI%) and centenarity index (CI%): new indicators to evaluate the characteristics of aging process in the Italian population. Arch Gerontol Geriatr 2007; 44: 271–6.

    Article  CAS  PubMed  Google Scholar 

  18. Kellgren J, Lawrence J. Atlas of Standard Radiographs: The Epidemiology of Chronic Rheumatism. Vol. 2. Oxford, Blackwell Scientific Publications 1963.

    Google Scholar 

  19. Kalichman L, Li L, Batsevich V, Kobyliansky E. Hand osteoarthritis in the Abkhazian population. Homo 2009; 60: 429–39.

    Article  CAS  PubMed  Google Scholar 

  20. Kalichman L, Li L, Batsevich V, Malkin I, Kobyliansky E. Prevalence, pattern and determinants of radiographic hand osteoarthritis in five Russian community-based samples. Osteoarthritis Cartilage 2010; 18: 803–9.

    Article  CAS  PubMed  Google Scholar 

  21. Malkin I, Karasik D, Livshits G, Kobyliansky E. Modelling of age-related bone loss using cross-sectional data. Ann Hum Biol 2002; 29: 256–70.

    Article  CAS  PubMed  Google Scholar 

  22. Malkin I, Ginsburg E. Program package for pedigree analysis (version MAN-2009). Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 2009.

    Google Scholar 

  23. Felson DT. An update on the pathogenesis and epidemiology of osteoarthritis. Radiol Clin North Am 2004; 42: 1–9.

    Article  PubMed  Google Scholar 

  24. Hochberg MC, Lethbridge-Cejku M, Plato CC, Wigley FM, Tobin JD. Factors associated with osteoarthritis of the hand in males: data from the Baltimore Longitudinal Study of Aging. Am J Epidemiol 1991; 134: 1121–7.

    CAS  PubMed  Google Scholar 

  25. An KN, Chao EY, Cooney WP, Linscheid RL. Forces in the normal and abnormal hand. J Orthop Res 1985; 3: 202–11.

    Article  CAS  PubMed  Google Scholar 

  26. Marks R, Allegrante JP. Comorbid disease profiles of adults with end-stage hip osteoarthritis. Med Sci Monit 2002; 8: CR305–9.

    PubMed  Google Scholar 

  27. Gabriel SE, Crowson CS, O’Fallon WM. Comorbidity in arthritis. J Rheumatol 1999; 26: 2475–9.

    CAS  PubMed  Google Scholar 

  28. Karasik D, Hannan MT, Cupples LA, Felson DT, Kiel DP. Genetic contribution to biological aging: the Framingham Study. J Gerontol A Biol Sci Med Sci 2004; 59: 218–26.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Kalichman L, Malkin I, Kobyliansky E. Osseographic score as a biomarker of biological aging. EAA (European Anthropological Association) Biennial Book 2008; 5: 1–14.

    Google Scholar 

  30. van der Kraan PM, van den Berg WB. Osteoarthritis in the context of ageing and evolution. Loss of chondrocyte differentiation block during ageing. Ageing Res Rev 2008; 7: 106–13.

    Article  PubMed  Google Scholar 

  31. Franceschi C, Capri M, Monti D, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128: 92–105.

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. Valery Batsevich & Eugene Kobyliansky

    Present address: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Authors and Affiliations

  1. Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva, 84105, Israel

    Leonid Kalichman

  2. Human Population Biology Research Unit, Department of Anatomy and Anthropology, Tel Aviv University, Tel Aviv, Israel

    Michael Korostishevsky

  3. Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia

    Valery Batsevich

  4. Lilian and Marcel Pollak Chair of Biological Anthropology, Tel Aviv, Israel

    Eugene Kobyliansky

Authors
  1. Leonid Kalichman
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  2. Michael Korostishevsky
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  3. Valery Batsevich
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  4. Eugene Kobyliansky
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Correspondence to Leonid Kalichman.

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Kalichman, L., Korostishevsky, M., Batsevich, V. et al. Hand osteoarthritis in longevity populations. Aging Clin Exp Res 23, 457–462 (2011). https://doi.org/10.1007/BF03325242

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  • DOI: https://doi.org/10.1007/BF03325242

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