Abstract
Prothiocarb, S-ethyl-N-(3-dimethy laminopropyl) thiocarbamic acid hydrochloride, a fungicide active against Oomycetes, possesses two modes of action. Its most common action is caused by the entire prothiocarb molecule. In this way it acts against Peronosporales like Pythium and Phytophthora, against Leptomitales like Apodachlya punctata and against part of the Saprolegniales like Aphanomyces species and Dictyuchus sterilis. For another part of the Sapro legniales, however, comprising Achlya radiosa, Pythiops is intermedia and Saprolegnia megasperma fungitoxicity must be ascribed to ethyl mercaptan released from prothiocarb.
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Alix, J.H., & Hayes, D., 1974. Properties of ribosomes and RNA synthesized by Escherichia coli grown in the presence of ethionine. III. Methylated proteins in 50 S ribosomes of E. coli EA 2. J. molec. Biol. 86: 139–159.
Bastiaansen, M.G., Pieroh, E.A. & Aelbers, E., 1974. Prothiocarb, a new fungicide to control Phytophthora fragariae in strawberries and Pythium ultimum in flowerbulbs. Meded. Fac. Landbouww. Rijksuniv. Gent 39: 1019–1925.
Colombani, F., Cherest, H. & Robichon-Szulmajster, H. de, 1975. Biochemical and regulatory effects of methionine analogues in Saccharomyces cerevisiae. J. Bact. 122: 375–384.
Davies, M.E., 1959. The nutrition of Phytophthora fragariae. Trans. Br. mycol. Soc. 42: 193–200.
Gleason, F.H., 1968. Nutritional comparisons in the Leptomitales. Am. J. Bot. 55: 1003–1010.
Griffin, D.H. & Breuker, C., 1969. Ribonucleic acid synthes is during the differentiation of sporangia in the water mold Achlya. J. Bact. 98: 698–696.
Kaars Sijpesteijn, A., Janssen, M.J. & Kerk, G.J.M. van der, 1957. Investigations on organic fungicides. XI. The role of metals and chelating agents in the fungitoxic action of sodium dimethyldithiocarbamate (NaDDC). Biochim. biophys. Acta 23: 550–557.
Kaars Sijpesteijn, A., Kerkenaar, A. & Overeem, J.C., 1974. Observations on selectivity and mode of action of prothiocarb (SN 41703). Meded. Fac. Landbouww. Rijksuniv. Gent 39: 1027–1034.
Kaars Sijpesteijn, A., 1977. Effects on fungal pathogens. In: R. W. Marsh (Ed.), Systemic Fungicides (2nd Edition). Longman, London, p. 131–159.
Parks, L.W., 1958. S-adenosylethionine and ethionine inhibition. J. biol. Chem. 232: 169–176.
Pieroh, E.A., Ahrens, C. & Schuhmacher, J., 1975a. Prothiocarb, a new systemic fungicide against Phycomycetous fungi. Rep. Inf. VIII Int. Pl. Prot. Congr. Moscow, Sect. III Chem. Control: 575–576.
Pieroh, E.A., Koehne, S. & Ahrens, C., 1975b. Erfahrungen mit Prothiocarb zur Bekämpfung von Phycomyceten im Zierpflanzenbau. Mitt. biol. BundAnst. Ldu. Forstw. 165: 147.
Roman, H., 1956. A system selective for mutations affecting the synthesis of adenine in yeast. C. r. Trav. Lab. Carlsberg 26: 299–314.
Shive, W. & Skinner, C.G., 1963. Amino acid analogues. In: R.M. Hochster & J.H. Quastel (Eds), Metabolic Inhibitors, Vol. 1. Academic Press, New York, p. 1–73.
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Kerkenaar, A., Kaars Sijpesteijn, A. On the mode of action of prothiocarb. Neth. J. Pl. Path. 83 (Suppl 1), 145–152 (1977). https://doi.org/10.1007/BF03041429
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DOI: https://doi.org/10.1007/BF03041429