Summary
We have shown that the baroreflex is partially maintained in patients anaesthetized with methoxyflurane following the administration of pancuronium. Initially heart rate responses are counteracted by the vagolytic effect of pancuronium, which might be explained by a muscarinic and/or ganglionic blocking property of the drug.
Résumé
Nous avons montré que la réponse à la stimulation des barorecepteurs est partiellement maintenue chez les patients anesthésiés au Méthoxyflurane suivant l’administration de Pancuronium. Initialement la réponse cardiaque est contrecarrée par l’effet vagolytique du Pancuronium, ce qui peut s’expliquer par la propriété muscarinique et/ou la propriété ganglioplégique du médicament.
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Supported in part by a Grant from the Medical Research Council of Canada.
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Duke, P.C., Mittler, G. & Wade, J.G. The effect of pancuronium on reflex regulation of heart rate in man. Canad. Anaesth. Soc. J. 21, 139–146 (1974). https://doi.org/10.1007/BF03013106
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DOI: https://doi.org/10.1007/BF03013106