Abstract
Defective apoptotic program due to the overexpression of the anti-apoptotic Bcl-2 protein of the outer mitochondrial membrane may be a cause of the poor response of malignant pheochromocytoma to131I-MIBG therapy. We report a case of malignant pheochromocytoma which showed early intense uptake and immediate rapid washout of99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2 and which was refractory to131I-MIBG therapy.
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Wakasugi, S., Kinouchi, T., Taniguchi, H. et al. A case of malignant pheochromocytoma with early intense uptake and immediate rapid washout of99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2. Ann Nucl Med 20, 325–328 (2006). https://doi.org/10.1007/BF02984651
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DOI: https://doi.org/10.1007/BF02984651