Abstract
Severe Combined Immunodeficiency (SCID) mice were maintained in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept. Their average litter size was 3.4, non-productive rate 27.2%, and weaned-to-born ratio 73.5%. Thymus glands of SCID mice were found to consist of a rudimentary medulla without cortex, and to contain few lymphocytes. Spleen follicles were empty, virtually devoid of lymphocytes. Lymph nodes had no clear cortex, totally appeared to be empty with few lymphocytes. Lymphoid tissues in submucosa of intestines were undeveloped. Circulating lymphocytes only comprised a small fraction of total leukocytes of peripheral blood (10–24%). Possible uses of SCID mice were discussed.
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References
Bosma GC, et al. A severe combined immunodeficiency mutation in the mouse. Nature 1983; 301:527.
Bosma GC, et al. The mouse mutation severe combined immunodeficiency (SCID) is on chromosome 16. Immunogenetics 1989; 29:54.
Dorshkind K, et al. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol 1984; 132:1804.
Custer RP, et al. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 1985; 120:464.
Mosier DE, et al. Transfer of a function human immune system to mice with severe combined immunodeficiency. Nature 1988; 335:256.
McCune JM, et al. The SCID- hu mouse: Murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241:1632.
Reddy S, et al. Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immuno-deficiency. Cancer Res 1987; 47:2456.
Reid SK, et al. Engraftment of immunedeficient mice with human hematopietic stem cells. Science 1988; 242:1706.
Ware CF, et al. Human, rat and mouse hybridoma secrete high levels of monoclonal antibodies following transplantation into mice with severe combined immunodeficiency disease (SCID). J Immunol Meth 1985; 85:353.
Bancroft GJ, et al. Regulation of macrophage Ia expression in mice with severe combined immunodeficiency: Induction of Ia expression by a T- cell independent mechanism. J Immunol 1986; 137:4.
Czitrom AA, et al. The function of antigenpresenting cells in mice with severe combined immunodeficiency. J Immunol 1985; 134:2276.
Dorshkind K, et al. Natural killer (NK) cells are present in mice with severe combined immunodeficiency (SCID). J Immunol 1985; 134:3798.
Hasui M, et al. Effector and precursor phenotypes of lymphokineactivated killer cells in mice with severe combined immu-nodeficiency (SCID) and athymic (Nude) mice. Cell Immunol 1989; 120:230.
Bosma C, et al. Evidence of functional lymphocytes in some (leaky) SCID mice. J Exp Med 1988; 167:1016.
Schuler W, et al. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 1986; 46: 963.
Keer JFR, et al. Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics. Br J Cancer 1972; 26:239.
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Wang, G., Chang, B., Li, Y. et al. Observation on husbandry and reproduction of mice with severe combined immunodeficiency and histological examination of their immune organs. Chinese Journal of Cancer Research 3, 6–13 (1991). https://doi.org/10.1007/BF02955261
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DOI: https://doi.org/10.1007/BF02955261