Summary
In a 3-centre study, 128 patients with endoscopically proven duodenal ulcers were treated with cimetidine 1g daily. One hundred and nineteen patients completed 4 weeks’ treatment: 91 of these had healed ulcers and 28 were unhealed. A further 18 patients were healed at 8 weeks and 3 more healed at 12 weeks.
One hundred patients entered an 11 month trial comparing cimetidine 400 mg at night with placebo. Ulcers relapsed in significantly fewer, 13/49 (26.%), patients on cimetidine compared with 26/51 (50.9%) patients on placebo. Abnormalities in laboratory data occurred in both treatment groups but did not warrant withdrawal of therapy.
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Bardhan, K. D., Saul, D. M., Edwards, J. L., Smith, P. M., Haggie, S. J., Wyllie, J. H., Duthie, H. L. and Fussey, I. V. 1979. Double-blind comparison of cimetidine and placebo in the maintenance of healing of chronic duodenal ulceration. Gut 20, 158.
Bianchi Porro, G., Cheli, R., Dobrilla, G., Verme, G., Molinari, F., Pera, A., Petrillo, M. and Valenti, M. 1978. Treatment of active duodenal ulcer with oral cimetidine: a multicentre controlled endoscopic trial. Digestion 17, 383.
Binder, H. J., Cocco, A., Crossley, R. J., Finkelstein, W., Font, R., Friedman, G., Groake, J., Hughes, W., Johnson, A. F., McGuigan, J. E., Summers, R., Vlahcevic, R., Wilson, E. C. and Winship, D. H. 1978. Cimetidine in the treatment of duodenal ulcer: a multicentre double blind study. Gastroenterology 74, 380.
Blackwood, W. S., Maudgal, D. P. and Northfield, T. C. 1978. Prevention by bedtime cimetidine of duodenal ulcer relapse. Lancet i, 626.
Blackwood, W. S. and Northfield, T. C. 1977.In Proceedings of the 2nd International Symposium on H2 Receptor Antagonists. Amsterdam. Excerpta Medica. p. 124.
Bodemar, G. and Walan, A. 1978. Maintenance treatment of recurrent peptic ulcer by cimetidine. Lancet i, 403.
Dronfield, M. W., Matchelor, A. J., Larkworthy, W. and Langman, M. J. S. 1979. Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long term effects. Gut 20, 526.
Eustace, I. E., Fitzgerald, O. and McMullin, J. P. 1978. Role of cimetidine in relapse—prevention of duodenal ulcers healed by cimetidine. Irish J. Med. Sc., 147, 272.
Gehan, E. A. 1965. The generalised Wilcoxen test for comparing arbitrarily single-censored samples. Biometrika 52, 203.
Gray, G. R., Smith, I. S., Mackenzie, I. and Gillespie, G. 1978. Long term cimetidine in the management of severe duodenal ulcer dyspepsia. Gastroenterology 74, 397.
Hetzel, D. J., Hansky, J., Shearman, D. J. C., Korman, M. G., Hecker, R., Taggart, G. J., Jackson, R. and Gabb, B. W. 1978. Cimetidine treatment of duodenal ulcer: short term clinical trial and maintenance study. Gastroenterology 74, 389.
Littman, A. and Kruss, D. M. 1978. Safety of cimetidine. Gastroenterology 74, 478.
Winship, D. H. 1978. Cimetidine in the treatment of duodenal ulcer. Gastroenterology 74, 402.
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Walters, J.M., Crean, P., Kelly, D. et al. Cimetidine and duodenal ulcer: A study of initial and low dosage maintenance treatment in Ireland. IJMS 149, 270–274 (1980). https://doi.org/10.1007/BF02939153
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DOI: https://doi.org/10.1007/BF02939153