Summary
In the rabbit, pancreatic duct ligation leads to serious disturbances of the pancreatic endocrine parenchyma. Immunocytochemical studies conducted over a short period (between 5 and 30 days post ligation) allow observation of a progressive dissociation of the Langerhans islets which initially affects the splenic part of the pancreas, a region where numerous large islets are found. This dissociation is followed by a dispersion of small heterologous endocrine cell clusters or isolated endocrine cells in a connective tissue which replace the exocrine parenchyma. On the 30th day after ligation ultrastructural studies show marked degranulation of the B cells demonstrating the great fragility of these cells. These observations of insular dissociation, scattering of the different endocrine cells and impairment of B cells are often reported in experimental and pathological studies of the pancreas
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Catala, J., Bonnafous, R., Dutrillaux, M.C. et al. Dissociation of Langerhans islets in the rabbit after pancreatic duct ligation. Virchows Archiv B Cell Pathol 52, 539–551 (1986). https://doi.org/10.1007/BF02889992
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DOI: https://doi.org/10.1007/BF02889992