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Effect of (−)N-[α-phenyl-β-(p-tolyl)ethyl] linoleamide on lipid levels in serum and liver in cholesterol-fed rats

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Lipids

Abstract

The effect of (−)N-[α-phenyl-β-(p-tolyl) ethyl] linoleamide (PTLA) on lipid levels in serum and liver was compared with that of sitosterols in rats maintained on a diet supplemented with 1% of cholesterol, 0.5% of ox bile extracts, and 10% of hydrogenated coconut oil for 8 weeks. When PTLA was added to the diet at a level of 0.1%, the mean liver cholesterol level of male rats was reduced to 41% of the control and that of female rats was reduced to 19% of the control. In female rats, which showed higher cholesterol levels in serum and liver than male rats after cholesterol feeding, PTLA lowered the liver cholesterol level even at 0.0008% in the diet. Serum cholesterol was lowered by PTLA but not so markedly as liver cholesterol. The inhibition of cholesterol deposition in the liver suggests that the interference with cholesterol absorption is one of the main actions of PTLA. Sitosterols showed a similar pattern of lipid-lowering action, but the potency was far less than that of PTLA.

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Authors and Affiliations

  1. Research and Development Center, Pharmaceuticals Division, Sumitomo Chemical Company Ltd., 2-1, 4-chome Takatsukasa, Takarazuka, Hyogo, Japan

    Akihiko Nagata, Shunji Aono & Hiroshi Nakatani

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  1. Akihiko Nagata
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  2. Shunji Aono
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  3. Hiroshi Nakatani
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Nagata, A., Aono, S. & Nakatani, H. Effect of (−)N-[α-phenyl-β-(p-tolyl)ethyl] linoleamide on lipid levels in serum and liver in cholesterol-fed rats. Lipids 11, 167–171 (1976). https://doi.org/10.1007/BF02532853

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  • DOI: https://doi.org/10.1007/BF02532853

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