Abstract
Actively balanced (‘Lilly’) stimulating current waveforms are generally considered to give very ‘safe’ stimulation. Although this is perfectly true, the specification of the necessary waveform generators in neurological prostheses demands additional complexity, and probably additional expense and development time as well. The paper and its companion enquire whether the use of simple, passively charged-balanced stimulating pulses is equally safe, provided the stimulation parameters and circuitry are designed with appropriate care. It is concluded that, in respect of safe deliverable charge density per pulse at the electrode, release of noxious products and stimulating effectiveness, simple pulses need give no worse performance; in some circumstances they may give better.
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Albery, W. J. andHitchman, M. L. (1971)Ring-disc electrodes. Clarendon, Oxford.
Berkley, C. (1965) Potential problems in long term stimulation. Digest of the 6th International Conference on Medical and Biological Engineering, Tokyo.
Biegler, T. (1969) An electrochemical and electron microscopic study of activation and roughening of platinum electrodes.J. Electrochem. Soc.,116, 1131–1137.
Brummer, S. B. andTurner, M. J. (1977b) Electrical stimulation with Pt electrodes I.IEEE Trans.,BME-24, 436–439.
Brummer, S. B. andTurner, M. J. (1977c) Electrical stimulation with Pt electrodes II.-—Ibid.,BME-24, 440–443.
Brummer, S. B. andMcHardy, J. andTurner, M. J. (1977) Electrical stimulation with Pt electrodes III.Brain Behav. Evol.,14, 10–22.
Brummer, S. B., Robblee, L. S. andLefko, J. L. (1981) Evaluation of electrode materials and their electrochemical reactions. NIH Contract NO1-NS-9-2315, sixth quarterly report, March.
Donaldson, N. de, N. andPerkins, T. A. (1983) Analysis of resonant coupled coils in the design of radio frequency transcutaneous links.Med. & Biol. Eng. & Comput.,21, 612–627.
Donaldson, P. E. K., Donaldson, N. de N. andBrindley, G. S. (1985) Life of Pt and Pt-Ir stimulating electrodes in neurological prostheses.-—Ibid.,23, 84–86.
Donaldson, N. de N. andDonaldson, P. E. K. (1986) When are actively balanced biphasic (‘Lilly’) stimulating pulses necessary in a neurological prosthesis? I Historical background; Pt resting potential; πQ studies.-—Ibid.,24, 41–49.
Doty, R. W. andBartlett, J. R. (1981) Stimulation of the brain via metallic electrodes. InElectrical stimulation research techniques.Patterson, M. M. andKesner, R. B. (Eds.), Academic Press, New York.
Gilman, S. (1965) Modification of the surface area of platinum electrodes by the application of single pulses.J. Electroanal. Chem.,9, 276–281.
Guyton, D. L. andHambrecht, F. T. (1974) Theory and design of capacitor electrodes for chronic stimulation.Med. & Biol. Eng.,12, 613–620.
Johnson, D. C., Napp, D. andBruckenstein, S. (1970) A ring-disc electrode study of the current/potential behaviour of platinum in 1.0 M sulphuric and 0.1 M perchloric acids.Electrochimica Acta,15, 1493–1509.
Loeb, J.C., McHardy, J., Kelliher, E. M. andBrummer, S. B. (1982) Neural prostheses. InBiocompatibility in clinical practice, vol. II.Williams, D. F. (Ed.) CRC Press, Chap. 8.
McHardy, J., Robblee, L. S., Marston, J. M. andBrummer, S. B. (1980) Electrical stimulation with Pt electrodes IV.Biomaterials,1, 129–134.
Mortimer, J. T., Kaufman, D. andRoessman, U. (1980) Intramuscular electrical stimulation: tissue damage.Ann. Biomed. Eng.,8, 235–244.
Palin, A. T. (1967) Methods for the determination, in water, of free and combined chlorine chlorine dioxide and chlorite, bromine iodine and ozone, using diethyl-p-phenylene, diamine.J. Inst. Water Engs.,21, 537–547.
Robblee, L. S., McHardy, J., Marston, J. M. andBrummer, S. B. (1980) Electrical stimulation with Pt electrodes B.Biomaterials,1, 135–139.
Untereker, D. F. andBruckenstein, S. (1974) A dissolution-redeposition mechanism for the roughening of platinum electrodes by cyclic potential programs.J. Electrochem. Soc.,121, 360–362.
Vines, R. G. (1963) Noble metals. InCorrosion resistance of metals and alloys.La Que, F. L. andCopson, H. R. (Eds.). Reinhold, New York.
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Donaldson, N.d.N., Donaldson, P.E.K. When are actively balanced biphasic (‘Lilly’) stimulating pulses necessary in a neurological prosthesis? II pH changes; noxious products; electrode corrosion; discussion. Med. Biol. Eng. Comput. 24, 50–56 (1986). https://doi.org/10.1007/BF02441605
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DOI: https://doi.org/10.1007/BF02441605