Abstract
Using clonal methods for assessment of hemopoietic and stromal cells and long-term bone marrow cell cultures, we have demonstrated heterogeneity of myelodysplastic syndrome. Low content of stromal precursor cells in native bone marrow, peculiarities in the formation of the stromal layer and its hemopoiesis-stimulating capacity in long-term cultures, and altered properties of stromal precursor cells in long-term cultures indicate defect in the stromal microenvironment in myelodysplastic syndrome.
Similar content being viewed by others
References
L. P. Gerasimova, N. S. Kislyak, E. A. Mamedova, and N. A. Finogenova,Gematol. Transfusiol., No. 3, 16–18 (1991).
L. J. Bendall, K. Kortlepel, and D. J. Gottlieb,Exp. Hematol.,25, 132–139 (1997).
J. M. Bennett, D. Catovsky, M. T. Daniel, and G. Flandrin,Br. J. Haematol.,33, 189–195 (1982).
L. H. Countinho, C. G. Geary, J. Chang,et al.,,75, 1–10 (1990).
S. Gartner and H. S. Kaplan,Proc. Natl. Acad. Sci. USA,77, 4756–4759 (1980).
L. Holmberg, K. Seidel, W. Leisenring, and B. Torok-Storb,Exp. Hematol.,22, 741 (1990).
N. V. Iscove and F. Sieber,,3, 32–43 (1975).
A. Jacobs,Eur. J. Cancer.,1142, 1113–1115 (1990).
S. Kaneko, S. Motomura, H. Ibayashi,et al., Br. J. Haematol.,51, 217–225 (1982).
M. Mencoboni, G. Castello, R. Lerza,et al., Eur. J. Haematol.,56, 148–152 (1996).
P. L. Pike and W. A. Robinson,J. Cell. Physiol.,76, 77–84 (1970).
T. Ruutu, S. Partanen, R. Lintula,et al., Scand. J. Haematol.,32, 395–402 (1984).
G. B. Tennat, L. N. Truran, and A. K. Burnet,Br. J. Haematol.,93, 66–67 (1996).
D. Zipori, N. Reichman, L. Arcavi,et al., Exp. Hematol.,13, 603–609 (1985).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 14–18, January, 1999
Rights and permissions
About this article
Cite this article
Gerasimova, L.P., Manakova, T.E., Tsvetaeva, N.V. et al. Functional activity of hemopoietic and stromal cells in various types of myelodysplastic syndrome. Bull Exp Biol Med 127, 10–13 (1999). https://doi.org/10.1007/BF02432789
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02432789