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DNA repair efficiency for ultraviolet induced damage

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Abstract

Ultraviolet radiation causes lesions in bacterial DNA which are repaired by several enzyme systems. Wide variations in the efficiency of repair for differentE. Coli strains are inadequately explained by a simple presence or absence of one or more repair systems. It is proposed that a major factor in the variations is the sensitivity of the repair systems themselves to ultraviolet induced interactions between proteins and the repair enzyme cistrons. An analytic approach is applied to pre-existing data to establish the numbers of thymine and cytosine bases in the repair cistrons, lending support to the model. The findings imply that bacteria will become sensitive to UV upon inhibition of one of four amino acids.

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Authors and Affiliations

  1. St. John's University and Manhattan Community College, New York, New York

    David R. Waldman

  2. Department of Physics, St. John's University, 11439, Jamaica, New York

    Robert W. Finkel

Authors
  1. David R. Waldman
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  2. Robert W. Finkel
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Waldman, D.R., Finkel, R.W. DNA repair efficiency for ultraviolet induced damage. J Biol Phys 1, 26–35 (1973). https://doi.org/10.1007/BF02308963

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  • DOI: https://doi.org/10.1007/BF02308963

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