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The role of radionuclide imaging in disease of the alimentary tract

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Abstract

The current status of radionuclide imaging studies of the liver, spleen, and pancreas is reviewed. Although current instrumentation and radiopharmaceuticals allow considerably better images than in the past, the overall accuracy of detecting liver metastases remains at 80%. The specificity of detecting hepatic space occupying disease has been enhanced by additional radonuclide studies which reveal the vascular and metabolic properties of the lesion.-The frequency of spleen imaging has increased since99mTc-labeled colloids have been used. In most instances, it is obtained as a coincidental portion of the liver scintigraphic examination although it has significant primary indicxations such as in the elucidation of masses in or trauma to the left upper quadrant of the abdomen.—Selenium-75 selenomethionine pancreatic scintigraphy is best performed with serial Anger Camera images. Interfering hepatic activity is best removed by electronic subtraction techniques; if available. Careful attention to patient selection for the procedure is important. The mean true-positive and negative rates are 86% and 20%, respectively.

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References

  1. Almersjo, O., Bengmark, S., Hafstrom, L., Rosengren, K.: Accuracy of diagnostic tools in malignant hepatic lesions.Am J Surg 217:663, 1974

    Google Scholar 

  2. Blau M: Biosynthesis of (75Se) selenomethionine and (75Se) selenocytine.Biochem Biophys Acta 79:387 1961

    Google Scholar 

  3. Blau M, Bender MA:75Se-selenomethionine for visualization of the pancreas by isotope scanning.Radiology 78:974, 1962

    Google Scholar 

  4. Blau M, Manske RF: The pancreas specificity of75Se-selenomethionine.J Nucl Med 2:102, 1961

    Google Scholar 

  5. Castagna J, Benfield JR, Yamada H, Johnson de: The reliability of liver scans and function tests in detecting metastases.Surg Gynec Obstet 134:463–466, 1972

    Google Scholar 

  6. Cederquist C, Nielson J: Value of liver function tests in the diagnosis of hepatic metastases in patiens with gastric cancer.Acta chir scand 138:604, 1972

    Google Scholar 

  7. Covington EE: The accuracy of liver photoscans.Am J Roentgenol 109:742–744, 1970

    Google Scholar 

  8. Drum de, Christacopoulos JS: Hepatic scintigraphy in clinical decision making.J Nucl Med 13:908–915, 1972

    Google Scholar 

  9. Du Priest RW, Haines JE, et al: A comparison of scintiscans and arteriograms for identifying metastatic intrahepatic tumors.Surg Gynec Obstet 136:705, 1973

    Google Scholar 

  10. Fischer J, Wolfe R: Scintillation scanning of the spleen using radiochromium.Ger Med Mon 8:89, 1963

    Google Scholar 

  11. Freeman LM, Mendell CH: Dynamic vascular scintiphotography of the liver. In:Radionuclide Studies of the Gastrointestinal System. Freeman LM, Blaufox, MD (eds.) New York; Grune and Stratton 1973

    Google Scholar 

  12. Gilday DL, Alderson PO: Scintigraphic evaluation of liver and spleen injury.Sem Nucl Med 4:357, 1974

    Google Scholar 

  13. Gould HR, Clemett AR, Rossi P: Radiologic diagnosis of splenic metastasis.Am J Roentgenol 109:733, 1976

    Google Scholar 

  14. Harvey E, Loberg M, Cooper M:99mTc-HIDA: A new radiopharmaceutical for hepatobiliary imaging.J Nucl Med 16:533, 1975

    Google Scholar 

  15. Haynie TP, Miale A: The pancreas. In:Clinical Scintillation Imaging. Freeman LM, Johnson PM (eds.) New York: Grune & Stratton, Publ. Second ed. p 601 1975

    Google Scholar 

  16. Jhingran SG, Jordan L, Jahns MF, Haynie TP: Liver scintigrams compared with alkaline phosphatase and BSP determinations in the detection of metastatic carcinoma.J Nucl Med 12:227–230, 1971

    Google Scholar 

  17. Krishnamurthy GT, Endow TS, Tubis M et al:99mTc-Penicillamine cholescintigraphy: Comparison with oral cholecystography.J Nucl Med 14:418, 1973

    Google Scholar 

  18. Lin S-R, Mansfield CM, Kramer S, et al: Liver scanning in patients with suspected or proved cancer.Am J Roentgenol 108:98–101, 1970

    Google Scholar 

  19. Loberg MD, Callery PS, Harvey EB, Faith WC, Cooper MD: Development of a chelating group for synthesis into drug and biochemical analogues.J Nucl Med 16:546, 1975

    Google Scholar 

  20. Lubin E, Lewitus J: Blood pool scanning in investigating hepatic mass lesions. In:Radionuclide Studies of the Gastrointestinal System. Freeman LM, Blaufox MD (eds.) New York, Grune and Stratton 1973

    Google Scholar 

  21. Lunia S, Parthasarathy KL, Bakshi S, Bender MA: An evaluation of99mTc-sulfer colloid liver scintiscans and their usefulness in metastatic workup.J Nucl Med 16:62–65, 1975

    Google Scholar 

  22. Lutzker L, Koenigsberg M, Meng C, Freeman LM: The role of radionuclide imaging in spleen trauma.Radiology 110:419, 1974

    Google Scholar 

  23. Miale A, Rodriguez-Antunnez A, Gill WM: Pancreas scanning after ten years.Sem Nucl Med 2:201, 1972

    Google Scholar 

  24. Nagler W, Bender MA, Blau M: Radioisotope photoscanning of the liver.Gastroenterology 44:36–43, 1963

    Google Scholar 

  25. Pearson HA, Cornelius EA, Schwartz A, Zelson JH, Wolfson SL, Spencer RP: Transfusion reversible functional asplenia in young children with sickle cell anemia.N Engl J Med 28:334, 1970

    Google Scholar 

  26. Pearson HA, Spencer RP, Cornelius EA: Functional asplenia in sickle cell anemia.N Engl J Med 281:923, 1969

    Google Scholar 

  27. Ronai PM, Baker RJ, Bellen JC, et al: Technetium99m-Pyridoxylidene-glutamate: A new hepatobiliary radiopharmaceutical.J Nucl Med 16:728, 1975

    Google Scholar 

  28. Rosenthall L: The application of colloidal radiogold and radioiodinated rose bengal in hepatobiliary disease.Am J Roentgenol 101:561, 1967

    Google Scholar 

  29. Rosenthall L: Intravenous radionuclide angiography prior to closed needle biopsy of focal lesions.Canad Med Assoc J 107:1193, 1972

    Google Scholar 

  30. Rosenthall L, Arzoumanian A, Lisbona R: The use of combined131I-rose bengal and bromsulfalein as a test of liver function.J Canad Assoc Radiol 23:245, 1972

    Google Scholar 

  31. Rosenthall L, Henry JN, Murphy DA, Freeman LM: Radiopertechnetate imaging of the Meckel's diverticulum.Radiology 105:371, 1972

    Google Scholar 

  32. Stirrett LA, Yuhl ET, Cassen B: Clinical applications of hepatic radioactivity survey.Am J Gastroenterol 21:310, 1954

    Google Scholar 

  33. Wilson FE, Preston DF, Overholt EL: Detection of hepatic neoplasm.JAMA 209:676, 1969

    Google Scholar 

  34. Yeh DJ, Leeper RD, Benua RS: Multiradionuclide studies of filling defects in liver and spleen of patients with cancer.J Nucl Med 16:583, 1975

    Google Scholar 

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Authors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Leonard M. Freeman M.D.

  2. The Montreal General Hospital, Montreal, Canada

    Leonard Rosenthall

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  1. Leonard M. Freeman M.D.
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Freeman, L.M., Rosenthall, L. The role of radionuclide imaging in disease of the alimentary tract. Gastrointest Radiol 1, 187–196 (1976). https://doi.org/10.1007/BF02256364

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