Abstract
The method of obtaining radioactively labeled14C-gossypol-acetic acid has been improved: from it have been synthesized14C-derivatives of gossypol and their complexes with N-polyvinylpyrrolidone. A comparative study has been made of the pharmacokinetics of batriden, megosin, and their water-soluble complexes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
C. M. Lyman, M. M. Trant, J. T. Cronin, and F. H. Odell, J. Am. Oil Chem. Soc.,46, 100 (1968).
M. B. Abou-Donia and C. M. Lyman, Toxicol. Appl. Pharmacol.,17, 163 (1970).
M. B. Abou-Donia and J. W. Dieckert, J. Nutr.,104, 754 (1974).
M. B. Abou-Donia and J. W. Dieckert, Lipids,5, 938 (1970).
C. L. Skutches and F. H. Smith, J. Am. Oil Chem. Soc.,51, 413 (1974).
J. Heilbron and H. M. Bunbury, Dictionary of Organic Compounds, London (1946) p. 1029 [sic].
T. Roberts, The Chromatography and Electrophoresis of Radiolabelled Compounds, Elsevier Scientific, Amsterdam (1978) [Russian translation, Mir, Moscow (1981), p. 46].
Kh. L. Ziyaev, L. Biktimirov, N. I. Baram, et al., Republic of Uzbekistan Patent No. 2158, Rasmii Akhborotnoma,4(6), 33 (1994).
A. I. Ismailov, N. I. Baram, L. Biktimirov et al., Republic of Uzbekistan Patent No. 2123, Rasmii Akhborotnoma,4(6), 14 (1994).
V. I. Sumin, N. I. Baram, and A. I. Ismailov, Ist All-Union Conference on the Problem of Biologically Active Compounds Labeled with Radioactive Isotopes [in Russian], Moscow (1985), p. 51.
A. S. Singin and T. S. Safonova, Khim.-Farm. Zh.,13, 10 (1979).
U. A. Aripov, A. D. Sakhibov, B. Z. Kasymov, Kh. L. Ziyaev, L. Biktimirov, N. I. Baram, and A. I. Ismailov, Khim.-Farm. Zh.,3, 269 (1983).
V. I. Sumin, N. I. Baram, and A. I. Ismailov, IInd All-Union Conference on the Problem of Biologically Active Compounds Labeled with Radioactive and Stable Isotopes [in Russian], Moscow (1988), p. 92.
V. I. Sumin, A. D. Sakhibov, and N. I. Baram, Evaluation of the Pharmacological Activity of Chemical Compounds: Principles and Approaches [in Russian], Moscow (1989), p. 314.
A. D. Sakhibov, B. Z. Kasymov, V. I. Sumin, N. I. Baram, and A. I. Ismailov, Khim.-Farm. Zh. (1990), dep. No. 3087-B90.
E. P. Mel'nikova, G. K. Korolev, A. N. Dedenkov, et al., Methods for the Individualization and Optimization of the Use of Drugs on the Basis of a Study of Their Pharmacokinetics, in: Abstracts of Lectures at an All-Union Conference [in Russian], Moscow, Part 2 (1982), p. 51.
Additional information
A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 162 70 71. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 810–818, November–December, 1997.
Rights and permissions
About this article
Cite this article
Sumin, V.I., Ismailov, A.I. & Baram, N.I. Synthesis of14C-radioactively labeled derivatives of gossypol and the study of their pharmacokinetics. Chem Nat Compd 33, 636–641 (1997). https://doi.org/10.1007/BF02249630
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02249630