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Selective removal of neuraminidase from influenza A2 viruses

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Summary

Selective solubilization of biologically active neuraminidase can be achieved by incubating influenza A2 virus with bromelain and reducing agents at 4° C. The viral core obtained possesses hemagglutinating activity and is immunogenic.

Zusammenfassung

Biologisch aktive Neuraminidase konnte durch Inkubation von Influenza A2-Viren mit Bromelin und reduzierenden Reagentien bei 4° C selektiv solubilisiert werden. Das dabei erhaltene Virus-Restpartikel enthält Hämagglutinin und ist immunogen.

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Authors and Affiliations

  1. Sandoz Forschungsinstitut, Wien, Austria

    H. Bachmayer & G. Schmidt

Authors
  1. H. Bachmayer
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  2. G. Schmidt
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Bachmayer, H., Schmidt, G. Selective removal of neuraminidase from influenza A2 viruses. Med Microbiol Immunol 158, 91–94 (1972). https://doi.org/10.1007/BF02120473

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  • DOI: https://doi.org/10.1007/BF02120473

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