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Influence of steroid treatment's duration in patients with active Crohn's disease

  • Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy
  • Short Communication Gastrointestinal Inflammation
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Abstract

Steroids are very useful drugs in the treatment of active Crohn's disease (CD), but clinical relapses after steroid withdrawal may be very high.

We investigated the efficacy of two steroid regimens of different duration in inducing remission and in maintaining it after drug suspension.

Patients with active CD were randomly assigned to scheme A, lasting 7 weeks (27 patients), or to scheme B, lasting 15 weeks (27 patients). Remission rates at the end of the treatment were 81% for scheme A and 85% for scheme B. Relapse rates at 6 months after stop** the treatment were 50% (11 patients) and 52% (12 patients), respectively.

Remission rates seem not to be influenced by the duration of the treatment, but patients recently treated with steroids showed a higher relapse rate if they received the short-duration treatment.

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References

  1. R. W. Summers, D. M. Switz, J. T. Sessions, J. M. Becktel, W. R. Best, F. Jr. Kern and J. W. Singleton,National Cooperative Crohn's Disease Study: Results of drug treatment. Gastroenterology77, 847–869 (1979).

    PubMed  Google Scholar 

  2. H. Malchow, K. Ewe, J. W. Brandes, H. Goebell, H. Ehms, H. Sommer and H. Jesdinsky,European Cooperative Crohn's Disease Study: Results of drug treatment. Gastroenterology86, 249–266 (1984).

    PubMed  Google Scholar 

  3. R. Modigliani, J. Y. Mary, J. F. Simon, A. Cortot, J. C. Soule, J. P. Gendre and E. Rene, GETAID,Clinical, biological, and endoscopic picture of attacks of Crohn's Disease. Evolution on prednisolone. Gastroenterology98, 811–818 (1990).

    PubMed  Google Scholar 

  4. R. M. Smith, J. Rodhes and D. L. Hughes,Effect of low dose steroids on clinical relapse in Crohn's disease. Gut19, 606–610 (1978).

    PubMed  Google Scholar 

  5. J. W. Singleton, D. H. Law, M. L. Kelley, H. S. Mekhjian and R. A. L. Sturdevant,National Cooperative Crohn's Disease Study: Adverse reactions to study drugs. Gastroenterology77, 870–883 (1979).

    PubMed  Google Scholar 

  6. W. Best, J. M. Becktel, J. W. Singleton and F. Kern,Development of a Crohn's disease activity index. Gastroenterology70, 439 (1976).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto di Clinica Medica e Gastroenterologia e Cattedra di Terapia Medica, Via Massarenti 9, Bologna

    G. De Simone, P. Iannone, C. Belloli, A. Evangelisti, M. Campieri, A. Belluzzi, P. Gionchetti, M. Tampieri, E. Bertinelli & L. Barbara

  2. Servizio di Farmacologia Clinica-Universita' di Bologna, Via Massarenti 9, Bologna

    C. Brignola & M. Miglioli

Authors
  1. C. Brignola
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  2. G. De Simone
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  3. P. Iannone
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  4. C. Belloli
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  5. A. Evangelisti
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  6. M. Campieri
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  7. A. Belluzzi
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  8. P. Gionchetti
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  9. M. Tampieri
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  10. E. Bertinelli
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  11. M. Miglioli
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  12. L. Barbara
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Brignola, C., De Simone, G., Iannone, P. et al. Influence of steroid treatment's duration in patients with active Crohn's disease. Agents and Actions 36 (Suppl 1), C90–C92 (1992). https://doi.org/10.1007/BF01991034

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  • DOI: https://doi.org/10.1007/BF01991034

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