SpringerLink
Log in

Interferon receptors and their role in interferon action

  • Multi-author Review
  • Recent Developments in Interferon Research
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Interferon (IFN)_proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of different kinds of cells but in relatively low numbers (102–104/cell). The relationship between IFN binding to receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Aguet, M., and Blanchard, B., High affinity binding of125-I-labeled mouse interferon to a specific cell surface receptor. Virology115 (1981) 249–261.

    Article  CAS  PubMed  Google Scholar 

  2. Aguet, M., Dembic, Z., and Merlin, G., Molecular cloning and expression of the human interferon-gamma receptor, p. 16 (Abstr.). 1988 Annual Meeting of the International Society for Interferon Research, Kyoto, Japan 1988a.

  3. Aguet, M., and Merlin, G., Production of a polyclonal antiserum against affinity purified human interferon-gamma receptors. J. Interferon Res.7 (1987) 683.

    Google Scholar 

  4. Aguet, M., Dembic, Z., and Merlin, G., Molecular cloning and expression of the human interferon-gamma receptor. Cell55 (1988b) 273–280.

    Article  CAS  PubMed  Google Scholar 

  5. Anderson, R. G. W., and Kaplan, J., Receptor-mediated endocytosis, in: Modern Cell Biology, vol. 1, pp. 1–52. Alan R. Liss Inc., New York 1983.

    Google Scholar 

  6. Branca, A. A., Interferon receptors. In Vitro cell. devl Biol.24 (1988) 155–165.

    Article  CAS  Google Scholar 

  7. Burwen, S. J. and Jones, A. L., The association of polypeptide hormones and growth factors with the nuclei of target cells. TIBC12 (1987) 159–162.

    CAS  Google Scholar 

  8. Caldron, J., Sheehan, K. C. F., Chance, C., Thomas, M. L., and Schreiber, R. D., Purification and characterization of the human interferon-gamma receptor from placenta. Proc. natl Acad. Sci. USA85 (1988) 4837–4841.

    Article  Google Scholar 

  9. Chany, C., Interferon receptors and interferon binding, in: Interferon, vol. 3: Mechanisms of production and action, pp. 11–32. Ed. A. B. Friedman. Elsevier Science Publishers B. V., Amsterdam 1984.

    Google Scholar 

  10. Cuatrecasas, P., Hormone Receptors, Membrane Phospholipids, and Protein Kinases. The Harvey Lectures, Series 80, (1986) pp. 89–128.

    Google Scholar 

  11. Engel, D. A., Snoddy, J., Toniato, E., and Lengyel, P., Interferons as gene activators: Close linkage of two interferon-activatable murine genes. Virology166 (1988) 24–29.

    Article  CAS  PubMed  Google Scholar 

  12. Epstein, C. J., and Epstein, L. B., Genetic control of the response to interferon. Tex. Rep. Biol. Med.41 (1982) 324–331.

    CAS  Google Scholar 

  13. Fidler, I. J., Fogler, W. E., Kleinerman, E. S., and Saiki, I., Abrogation of species specificity for activation of tumorcidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes. J. Immun.135 (1985) 4289–4296.

    Article  CAS  PubMed  Google Scholar 

  14. Friedman, R. L., and Stark, G. R., α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature314 (1985) 637–639.

    Article  CAS  PubMed  Google Scholar 

  15. Fujita, T., Sakakibara, J., Sudo, Y., Miyamoto, M., Kimura, Y., and Taniguchi, T., Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-β regulatory elements. EMBO J. 91988) 3397–3405.

  16. Goldfine, I. D., Clawson, E. A., Purrello, F., and Vigneri, R., Action of insulin at the nuclear envelope. Molec. cell. Biochem.48 (1982) 3–14.

    Article  CAS  PubMed  Google Scholar 

  17. Gorski, J., The nature and development of steroid hormone receptors. Experientia42 (1986) 744–750.

    Article  CAS  PubMed  Google Scholar 

  18. Grossberg, S. E., Interferons: An overview-general biological and biochemical properties, in: Mechanisms of Interferon Actions, pp. 1–32. Ed. L. M. Pfeffer. CRC Press, New York 1987.

    Google Scholar 

  19. Grossberg, S. E., Kushnaryov, V. M., MacDonald, H. S., and Sedmak, J. J., Nuclear localization of internalized interferons-beta and-gamma: A role for nuclear receptors, in: The Biology of the Interferon System, pp. 53–56. Eds K. Cantell and H. Schellekens. Martinus Nijhoff Publishers, Dordrecht 1987.

    Google Scholar 

  20. Hannigan, G., and Williams, B. R. G., Transcriptional regulation of interferon-responsive genes is closely linked to interferon receptor occupancy. EMBO J.5 (1986) 1607–1613.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Higashi, Y., and Sokawa, Y., Microinjection of interferon and 2′5′-oligoadenylate into mouse L-cells and their effects on virus growth. J. Biochem.91 (1982) 2021–2028.

    Article  CAS  PubMed  Google Scholar 

  22. Huez, G., Silhol, M., and Lebleu, B., Microinjected interferon does not promote an antiviral response in HeLa cells. Biochem. biophys. Res. Commun.110 (1983) 155–160.

    Article  CAS  PubMed  Google Scholar 

  23. Inglot, A. D., Interferons and growth factors viewed as two families of hormones with opposing actions. Tex. Rep. Biol. Med.41 (1982) 402–410.

    CAS  Google Scholar 

  24. Kushnaryov, V., DeBruin, J., Sedmak, J. J., MacDonald, H. S., Kushnaryov, T., and Grossberg, S. E., Quantitation of low numbers of interferon molecules by immunogold staining of section of Lowicryl K 4 M-embedded cells. J. Electron Microsc.35 Suppl. (1986a) 2309–2310.

    Google Scholar 

  25. Kushnaryov, V. M., MacDonald, H. S., DeBruin, J., LeMense, G. P., Sedmak, J. J., and Grossberg, S. E., Internalization and transport of mouse beta-interferon into the cell nucleus. J. Interferon Res.6 (1986b) 241–245.

    Article  CAS  PubMed  Google Scholar 

  26. Kushnaryov, V. M., MacDonald, H. S., LeMense, G., DeBruin, J., Sedmak, J. J., and Grossberg, S. E., Quantitative analysis of mouse interferon-beta receptor-mediated endocytosis and nuclear entry. Cytobios53 (1988) 185–197.

    CAS  PubMed  Google Scholar 

  27. Kushnaryov, V. M., MacDonald, H. S., Sedmak, J. J., and Grossberg, S. E., Ultrastructural distribution of interferon receptor sites on mouse L cells grown in suspension: Ganglioside blockade of ligand binding. Infect. Immun.40 (1983) 320–329.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Kushnaryov, V. M., MacDonald, H. S., Sedmak, J. J., and Grossberg, S. E., Murine interferon-beta receptor-mediated endocytosis and nuclear membrane binding. Proc. natl Acad. Sci. USA82 (1985) 3281–3285.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kushnaryov, V. M., MacDonald, H. S., Sedmak, J. J., and Grossberg, S. E., The cellular internalization of recombinant gamma interferon differs from that of natural interferon-gamma. Biochem. biophys. Res. Commun.157 (1988) 109–114.

    Article  CAS  PubMed  Google Scholar 

  30. Kushnaryov, V. M., Sedmak, J. J., Bendler, J. W. III, and Grossberg, S. E., Ultrastructural localization of interferon receptors on the surfaces of cultured cells and erythrocytes. Infect. Immun.36 (1982) 811–821.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Langer, J. A., and Pestka, S., Interferon receptors. Immun. Today9 (1988) 393–400.

    Article  CAS  PubMed  Google Scholar 

  32. Lau, A. S., Hannigan, G. E., Freedman, M. H., and Williams, B. R. G., Begulation of interferon receptors expression in human blood lymphocytes in vitro and during IFN therapy. J. clin. Invest77 (1986) 1632–1638.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Levy, D. E., Kessler, D. S., Pine, R., Reich, N., and Darnell, J. E. Jr, Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Devl.2 (1988) 383–393.

    Article  CAS  Google Scholar 

  34. MacDonald, H. S., Kushnaryov, V. M., Hevner, R., Sedmak, J. J., and Grossberg, S. E., Mouse beta-interferon reduces RNA efflux from isolated nuclei, J. Interferon Res.6 (1986a) 247–250.

    Article  CAS  PubMed  Google Scholar 

  35. MacDonald, H. S., Kushnaryov, V. M., Sedmak, J. J., and Grossberg, S. E., Transport of gamma-interferon into the cell nucleus may be mediated by nuclear membrane receptors. Biochem. biophys. Res. Commun.138 (1986b) 254–260.

    Article  CAS  PubMed  Google Scholar 

  36. Maxwell, B. L., Talpaz, M., and Gutterman, J. U., Down regulation of peripheral blood cell interferon receptors in chronic myelogenous leukemic patients undergoing human IFN (HuIFN-α) therapy. Int. J. Cancer36 (1987) 23–28.

    Article  Google Scholar 

  37. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., and Taniguchi, T., Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell54 (1988) 903–913.

    Article  CAS  PubMed  Google Scholar 

  38. Novick, D., Orchansky, P., Revel, M., and Rubinstein, M., The human interferon-gamma receptor. J. biol. Chem.262 (1987) 8483–8487.

    Article  CAS  PubMed  Google Scholar 

  39. Novick, D., Rubinstein, M., and Fischer, D. G., Anti-idiotypic antibodies to the idiotypes of anti-interferon-gamma, alpha and beta antibodies as probes to study the interferon receptor. J.Interferon Res.7 (1987) 769.

    Google Scholar 

  40. Orchansky, P., Rubinstein, M., and Fischer, D. G., The interferon-gamma receptor in human monocytes is different from the one in nonhematopoietic cells. J. Immun.136 (1986) 169–173.

    Article  CAS  PubMed  Google Scholar 

  41. Ortaldo, J. R., Mason, A., Rehberg, E., Kelder, B., Harvey, D., Osheroff, P., Pestka, S., and Herberman, R. B., Augmentation of NK activity with recombinant and hybrid recombinant human leukocyte interferons, in: The Biology of the Interferon System, pp. 353–358. Eds E. DeMaeyer and H. Schellekens. Elsevier Science Publishers, Amsterdam 1983.

    Google Scholar 

  42. Osheroff, P. L., Chiang, T., and Manousos, D., Interferon-like activity in an anti-interferon anti-idiotypic hybridoma antibody. J. Immun.135 (1985) 306–313.

    Article  CAS  PubMed  Google Scholar 

  43. Pastan, I. H., and Willingham, M. C., Receptor-mediated endocytosis: Coated pits, receptorsomes and the Golgi. TIBC8 (1983) 250–254.

    CAS  Google Scholar 

  44. Pestka, S., Langer, J. A., Zoon, K. C., and Samuel, C. E., Interferons and their actions. A. Rev. Biochem.56 (1987) 727–777.

    Article  CAS  Google Scholar 

  45. Revel, M., and Chebath, J., Interferon-activated genes. TIBC11 (1986) 166–170.

    CAS  Google Scholar 

  46. Rubinstein, M., and Orchansky, P., The interferon receptors. CRC Crit. Rev. Biochem.21 (1986) 249–275.

    Article  CAS  PubMed  Google Scholar 

  47. Sakaguchi, A. Y., Stevenson, D., and Gordon, I., Species specificity of interferon action: A functioning homospecific nucleus is required for induction of antiviral activity in heterokaryons. Virology116 (1982) 441–453.

    Article  CAS  PubMed  Google Scholar 

  48. Sanceau, J., Sondermeyer, P., Beranger, F., Falcoff, R., and Vaquero, C., Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells. Proc. natl Acad. Sci. USA84 (1987) 2906–2910.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Schreiber, R. D., Calderon, J., Sheehan, K. C., and Khurana, N., Purification and characterization of the human IFN-gamma receptor. 1988 Annual Meeting of the International Society for Interferon Research, p. 16 (Abstr.) Kyoto, Japan 1988.

  50. Sedmak, J. J., MacDonald, H. S., and Kushnaryov, V. M., Lanthanide ion enhancement of interferon binding to cells. Biochem. biophys. Res. Commun.137 (1986) 480–485.

    Article  CAS  PubMed  Google Scholar 

  51. Shulman, L., Fellous, M., Goldberg, M., and Revel, M., Molecular cloning of the human IFN-α/β receptor cDNA. 1988 Annual Meeting of the International Society for Interferon Research, p. 17 (Abstr.) Kyoto, Japan 1988.

  52. Tanaka, M., Kimura, K., and Yoshida, S., Inhibition of mammalian DNA polymerases by recombinant α-interferon and gamma-interferon. Cancer Res.47 (1987) 5971–5974.

    CAS  PubMed  Google Scholar 

  53. Taylor, J. L., Sabran, J. L., and Grossberg, S. E., The cellular effects of interferons, in: Interferons and Their Applications, Handbook of Experimental Pharmacology, vol. 71, pp. 169–204. Eds P. E. Came and W. A. Carter. Springer-Verlag, New York 1984.

    Chapter  Google Scholar 

  54. Zoon, K. C., and Arnheiter, H., Studies of the interferon receptors. Pharmac. Ther.24 (1984) 259–278.

    Article  CAS  Google Scholar 

  55. Zoon, K. C., Arnheiter, H., Zur Needen, D., Fitzgerald, D. J. P., and Willingham, M. C., Human interferon alpha enters cells by receptor-mediated endocytosis. Virology310 (1983) 195–203.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226, Milwaukee, Wisconsin, USA

    S. E. Grossberg, J. L. Taylor & V. M. Kushnaryov

Authors
  1. S. E. Grossberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. L. Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. M. Kushnaryov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grossberg, S.E., Taylor, J.L. & Kushnaryov, V.M. Interferon receptors and their role in interferon action. Experientia 45, 508–513 (1989). https://doi.org/10.1007/BF01990499

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01990499

Key words

Search

Navigation