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Crystalline cytoplasmic inclusions in the liver cells of two mongrel dogs

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Research in Experimental Medicine

Summary

Crystalline inclusions were found in the cytoplasmic matrix of the liver cells in 2 out of 5 healthy mongrel dogs. The crystals were rectangular, with fine granular structure and free from the surrounding membrane. Their appearance was different from the intramitochondrial crystalline inclusions described in human and dog livers, as well as from those observed in the livers of other species. The significance of this unique finding remains unclear, but it is suggested that these inclusions represent crystalized protein.

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References

  1. Blair, O. M., Stenger, R. J., Hopkins, R. W., Simeone, F. A.: Hepatocellular ultrastructure in dogs with hypovolemic shock. Lab. Invest.18, 172 (1968)

    PubMed  Google Scholar 

  2. Cawley, J. C., Barker, C. R., Britchford, R. D., Smith, J. L.: Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia. Clin. Exp. Immunol.13, 407 (1973)

    PubMed  Google Scholar 

  3. Clark, C., Rydell, R. E., Kaplan, M. E.: Frequent association of IgMl with crystalline inclusions in chronic lymphatic leukemic lymphocytes. New Engl. J. Med.289, 113 (1973)

    PubMed  Google Scholar 

  4. Cohnen, G., Douglas, S. D., König, E., Bremer, K., Brittinger, G.: Crystalloid intracytoplasmic inclusions in lymphocytes of a patient with chronic lymphocytic leukemia. Mount Sinai J. Med.40, 249 (1973)

    Google Scholar 

  5. De Man, J. C. H., Meiners, W. B. H.: Crystals of protein nature in the cytoplasm of lymphatic cells in a case of lymphoreticular malignancy. Blood20, 492 (1962)

    PubMed  Google Scholar 

  6. Djaldetti, M., Mandel, E. M., Fishman, P., Bessler, H., Lewinski, U.: Intramitochondrial crystalline inclusions in metastatic hypernephroma of the liver. Biomed. Exp.21, 158 (1974)

    Google Scholar 

  7. Ericsson, J. L. F., Orrenius, S., Holm, I.: Alterations in canine liver cells induced by protein deficiency: ultrastructural and biochemical observations. Exp. Mol. Pathol.5, 329 (1966)

    PubMed  Google Scholar 

  8. Fawcett, D. W.: The Cell. An Atlas of Fine Structure, p. 321. Philadelphia: Saunders 1969

    Google Scholar 

  9. Ghadially, F. N.: Ultrastructural Pathology of the Cell, pp. 70, 170, 244. London: Butterworths 1975

    Google Scholar 

  10. Ghadially, F. N.: Personal communication

  11. Goldberg, A. F.: An unusual lymphomatous disease associated with intracytoplasmic crystals in lymphoplasmocytoid cells. Blood16, 1693 (1960)

    PubMed  Google Scholar 

  12. Mandel, E. M., Fishman, P., Kissin, E., Har-Zahav, L., Djaldetti, M.: Intramitochondrial crystalline inclusions in the liver of a patient with hyperthyroidism. Acta Hepatogastroenterol.23, 182 (1976)

    Google Scholar 

  13. Mandel, E. M., Lewinski, U., Gafter, U., Weiss, S., Freidin, N., Djaldetti, M.: The presence of hepatic intramitochondrial crystalline inclusions in routine liver biopsies. Am. J. Med. Sci.274, 61 (1977)

    PubMed  Google Scholar 

  14. Mennemeyer, R., Hammar, S. P., Cathey, W. J.: Malignant lymphoma with intracytoplasmic IgM crystalline inclusions. New Engl. J. Med.291, 960 (1974)

    PubMed  Google Scholar 

  15. Swenson, O., Grana, L., Inouye, T., Donnellan, W. L.: Immediate and long-term effects of acute hepatic ischemia. Arch. Surg.95, 451 (1967)

    PubMed  Google Scholar 

  16. Shiraki, K., Neustein, H. B.: Intramitochondrial crystalloids and amorphous granules. Occurrence in experimental hepatic ischemia in dogs. Arch. Pathol.91, 32 (1971)

    PubMed  Google Scholar 

  17. Voelz, H.: Structural comparison between intramitochondrial and bacterial crystalloids. J. Ultrastruct. Res.25, 29 (1968)

    PubMed  Google Scholar 

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Djaldetti, M., Feller, N. Crystalline cytoplasmic inclusions in the liver cells of two mongrel dogs. Res. Exp. Med. 173, 279–283 (1978). https://doi.org/10.1007/BF01851499

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  • DOI: https://doi.org/10.1007/BF01851499

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