Summary
Crystalline inclusions were found in the cytoplasmic matrix of the liver cells in 2 out of 5 healthy mongrel dogs. The crystals were rectangular, with fine granular structure and free from the surrounding membrane. Their appearance was different from the intramitochondrial crystalline inclusions described in human and dog livers, as well as from those observed in the livers of other species. The significance of this unique finding remains unclear, but it is suggested that these inclusions represent crystalized protein.
Similar content being viewed by others
References
Blair, O. M., Stenger, R. J., Hopkins, R. W., Simeone, F. A.: Hepatocellular ultrastructure in dogs with hypovolemic shock. Lab. Invest.18, 172 (1968)
Cawley, J. C., Barker, C. R., Britchford, R. D., Smith, J. L.: Intracellular IgA immunoglobulin crystals in chronic lymphocytic leukaemia. Clin. Exp. Immunol.13, 407 (1973)
Clark, C., Rydell, R. E., Kaplan, M. E.: Frequent association of IgMl with crystalline inclusions in chronic lymphatic leukemic lymphocytes. New Engl. J. Med.289, 113 (1973)
Cohnen, G., Douglas, S. D., König, E., Bremer, K., Brittinger, G.: Crystalloid intracytoplasmic inclusions in lymphocytes of a patient with chronic lymphocytic leukemia. Mount Sinai J. Med.40, 249 (1973)
De Man, J. C. H., Meiners, W. B. H.: Crystals of protein nature in the cytoplasm of lymphatic cells in a case of lymphoreticular malignancy. Blood20, 492 (1962)
Djaldetti, M., Mandel, E. M., Fishman, P., Bessler, H., Lewinski, U.: Intramitochondrial crystalline inclusions in metastatic hypernephroma of the liver. Biomed. Exp.21, 158 (1974)
Ericsson, J. L. F., Orrenius, S., Holm, I.: Alterations in canine liver cells induced by protein deficiency: ultrastructural and biochemical observations. Exp. Mol. Pathol.5, 329 (1966)
Fawcett, D. W.: The Cell. An Atlas of Fine Structure, p. 321. Philadelphia: Saunders 1969
Ghadially, F. N.: Ultrastructural Pathology of the Cell, pp. 70, 170, 244. London: Butterworths 1975
Ghadially, F. N.: Personal communication
Goldberg, A. F.: An unusual lymphomatous disease associated with intracytoplasmic crystals in lymphoplasmocytoid cells. Blood16, 1693 (1960)
Mandel, E. M., Fishman, P., Kissin, E., Har-Zahav, L., Djaldetti, M.: Intramitochondrial crystalline inclusions in the liver of a patient with hyperthyroidism. Acta Hepatogastroenterol.23, 182 (1976)
Mandel, E. M., Lewinski, U., Gafter, U., Weiss, S., Freidin, N., Djaldetti, M.: The presence of hepatic intramitochondrial crystalline inclusions in routine liver biopsies. Am. J. Med. Sci.274, 61 (1977)
Mennemeyer, R., Hammar, S. P., Cathey, W. J.: Malignant lymphoma with intracytoplasmic IgM crystalline inclusions. New Engl. J. Med.291, 960 (1974)
Swenson, O., Grana, L., Inouye, T., Donnellan, W. L.: Immediate and long-term effects of acute hepatic ischemia. Arch. Surg.95, 451 (1967)
Shiraki, K., Neustein, H. B.: Intramitochondrial crystalloids and amorphous granules. Occurrence in experimental hepatic ischemia in dogs. Arch. Pathol.91, 32 (1971)
Voelz, H.: Structural comparison between intramitochondrial and bacterial crystalloids. J. Ultrastruct. Res.25, 29 (1968)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Djaldetti, M., Feller, N. Crystalline cytoplasmic inclusions in the liver cells of two mongrel dogs. Res. Exp. Med. 173, 279–283 (1978). https://doi.org/10.1007/BF01851499
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851499