Abstract
We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13 → q23 region of chromosome 5.
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Mohandas, T., Heinzmann, C., Sparkes, R.S. et al. Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5. Somat Cell Mol Genet 12, 89–94 (1986). https://doi.org/10.1007/BF01560731
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DOI: https://doi.org/10.1007/BF01560731