Summary
Thymus-derived peripheral blood lymphocytes were studied in untreated (n=18), methimazoletreated (n=28) thyrotoxicosis, after radioiodine (n=14), in Hashimoto thyroiditis (n=7) and in euthyroid goiter (n=7). The results were compared with normal persons (n=40) without thyroid disease.
There was no significant difference in the total and relative counts of T-cells either between the different groups nor compared with the controls.
These findings confirm that T-cells in peripheral blood cannot give any information about activity or prognosis of the various thyroid diseases. Thus T-cells give no further suggestion concerning the possible pathogenetic role of cell-mediated-immunity.
Zusammenfassung
T-Lymphocyten wurden bei 18 Patienten mit unbehandelter florider Hyperthyreose, 28 Patienten mit „kompensierter Hyperthyreose“ nach thyreostatischer Langzeitbehandlung mit Carbimazol oder Methimazol in Kombination mit L-Thyroxin, 14 Hyperthyreosen nach 131-Jodbehandlung, 7 Hashimoto-Thyreoiditiden und 7 blanden Strumen bestimmt und mit einem Normalkollektiv von 40 Schilddrüsengesunden verglichen. Ein Unterschied des prozentualen Anteils und der Absolutzahlen der T-Lymphocyten ließ sich weder zwischen den Gruppen mit Schilddrüsenerkrankungen noch im Vergleich zum Normalkollektiv sichern. Nach diesen Befunden sind die Absolut- und Relativwerte der T-Lymphocyten im Blut keine geeigneten Parameter für die Beurteilung der Aktivität und Prognose der verschiedenen Schilddrüsenerkrankungen und gestatten keine Aussage über die pathogenetisch vielleicht relevante Bedeutung der zellvermittelten Immunität.
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Abbreviations
- LATS:
-
Long Acting Thyroid Stimulator
- HTS:
-
Human Thyroid Stimulator
Literatur
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Hackenberg, K., Cohnen, G. & Reinwein, D. T-Lymphocyten bei Schilddrüsenerkrankungen. Klin Wochenschr 54, 987–993 (1976). https://doi.org/10.1007/BF01468950
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DOI: https://doi.org/10.1007/BF01468950