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Skin levels of vasoactive intestinal polypeptide in atopic dermatitis

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Summary

Atopic dermatitis (AD) can be exacerbated by various factors, including emotional stress, scratching and sweating. The aim of the present study was to evaluate the hypothesis that the inflammatory reaction in AD is also neurogenic. For this purpose, the levels of vasoactive intestinal polypeptide were measured radioimmunologically in whole-tissue homogenates of lesional skin of 13 patients with atopic dermatitis. Radioimmunoassay was performed using an antiserum, AH78, recognizing the carboxy-terminal fragment vasoactive intestinal polypeptide (22–28). Vasoactive intestinal polypeptide immunoreactivity was detected in relatively low amounts in control skin (0.428±0.08 pmol/g tissue), whereas a marked increase in the peptide was observed in lesional skin of patients with atopic dermatitis (5.62±1.25 pmol/g tissue). These results seem to suggest that vasoactive intestinal polypeptide could have a pathogenetic relevance in skin lesions of atopic dermatitis.

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Authors and Affiliations

  1. Institute of Dermatology, University of Modena, Via del Pozzo 71, I-41100, Modena, Italy

    C. Pincelli, F. Fantini & A. Giannetti

  2. Institute of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy

    P. Romualdi & G. Lesa

Authors
  1. C. Pincelli
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  2. F. Fantini
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  3. P. Romualdi
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  4. G. Lesa
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  5. A. Giannetti
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Pincelli, C., Fantini, F., Romualdi, P. et al. Skin levels of vasoactive intestinal polypeptide in atopic dermatitis. Arch Dermatol Res 283, 230–232 (1991). https://doi.org/10.1007/BF01106107

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  • DOI: https://doi.org/10.1007/BF01106107

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