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Mixed-ligand complexes of gold(I) and silver(I) with heterocyclic thiones

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Summary

Novel mixed-ligand complexes of Ag1 and Au1 containing triphenylphosphine (TPP) and heterocyclic thiones, of general formula [TPP−M−L]Cl and [(TPP)2−M−L]Cl, where L=imidazolidine-2-thione (Imt), 1,3-diazinine-2-thione (Diaz) or N-isopropylimidazolidine-2-thione (iPrImt) have been prepared. The spectroscopic data are consistent with S-donation in all complexes. The magnitude of high-field shift in carbon-13 n.m.r. of the thioureide carbon on complexation is interpreted in terms of coordination geometry around the metal atoms. The mixed-ligand complexes are structurally similar to some of the commonly used antiarthritic Au1 drugs and are thus potentially useful in chemotherapy.

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Authors and Affiliations

  1. Department of Chemistry King Fahd University of Petroleum and Minerals, KFUPM Box 1830, 31261, Dhahran, Saudi Arabia

    M. Sakhawat Hussain, M. Latif Hossain & Abderehman Al-Arfaj

Authors
  1. M. Sakhawat Hussain
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  2. M. Latif Hossain
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  3. Abderehman Al-Arfaj
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Hussain, M.S., Hossain, M.L. & Al-Arfaj, A. Mixed-ligand complexes of gold(I) and silver(I) with heterocyclic thiones. Transition Met Chem 15, 120–125 (1990). https://doi.org/10.1007/BF01023900

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