Summary
The present study reports unusual, long, tubular, rod-shaped cytoplasmic inclusions found in the stromal cells of a cerebellar hemangioblastoma, associated with von Hippel-Lindau syndrome. These inclusions have two layers of circular, laminated filaments, and longitudinally arranged filaments; and appear similar to the so-called “Hirano bodies”, which have been previously found in normal and various pathologic conditions of the brain tissue, skeletal muscle cells in myopathy, and interstitial cells of the testis. A review of previous ultrastructural studies of cerebellar hemangioblastoma shows several different types of cytoplasmic inclusions, but none are found to be identical to the present report.
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The study is supported in part by a grant from U. S. P. H. S. No. 1RO1CA16096.
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Fu, YS., Ward, J. & Young, H.F. Unusual, rod-shaped cytoplasmic inclusions (Hirano bodies) in a cerebellar hemangioblastoma. Acta Neuropathol 31, 129–135 (1975). https://doi.org/10.1007/BF00688147
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DOI: https://doi.org/10.1007/BF00688147