SpringerLink
Log in

Concanavalin A-induced suppressor cell activity and in vitro immunoglobulin secretion in rheumatoid arthritis: Correlation with clinical and immunological parameters

  • Originals
  • Published:
Rheumatology International Aims and scope Submit manuscript

Summary

Concanavalin A-induced suppressor cell activity was found moderately but significantly (P<0.05) decreased in RA patients treated with nonsteroidal antiinflammatory drugs (31±7% suppression) as compared to patients on remission-inducing drugs, such as gold, penicillamine, or chloroquine (51±6%) or to healthy individuals (50±6%). Also, lymphocytes from patients with antibodies to collagen mediated lower suppression (33±7%) than lymphocytes from patients without evidence for these autoantibodies (61±11%). No significant difference between patients and controls or between individual groups of patients were observed in regard to IgM and IgG secretion induced by pokeweed mitogen. Thus, although no indication for a severe derangement of regulatory cells in peripheral blood of RA patients could be observed in this study, a slight deficiency of ConA-inducible suppressor cells that may be reverted by remission-inducing drugs seems to be present in RA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Waldmann TA, Broder S, Blaese RM, Durm M, Blackman M, Strober W (1974) Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinemia. Lancet II:609–613

    Google Scholar 

  2. Shou L, Schwartz SA, Good RA (1976) Suppressor cell activity after Concanavalin A treatment of lymphocytes from normal donors. J Exp Med 143:1100–1110

    Google Scholar 

  3. Bresnihan B, Jasin HE (1977) Suppressor function of peripheral blood mononuclear cells in normal individuals and patients with systemic lupus erythematosus. J Clin Invest 59:106–116

    Google Scholar 

  4. Sakane T, Steinberg AD, Green I (1978) Studies of immune functions of patients with systemic lupus erythematosus. I. Dysfunction of suppressor T-cell activity related to impaired generation of, rather than response to, suppressor cells. Arthritis Rheum 21:657–664

    Google Scholar 

  5. Sagawa A, Abdou NI (1978) Suppressor cell dysfunction in systemic lupus erythematosus — cells involved and in vitro correction. J Clin Invest 62:789–796

    Google Scholar 

  6. Strelkauskas AJ, McCallery RT, McDowell J, Borel Y, Schlossman SF (1978) Direct evidence for loss of human suppressor cell activity during active autoimmune disease. Proc Natl Acad Sci USA 10:5150–5154

    Google Scholar 

  7. Hodgson HJF, Wands JR, Iselbacher KJ (1978) Decreased suppressor cell activity in inflammatory bowel disease. Clin Exp Immunol 32:451–458

    Google Scholar 

  8. Smolen JS, Gangl A, Menzel EJ, Wolf Ch, Knapp W (submitted) Lymphocyte transformation and suppressor cell activity in inflammatory bowel disease

  9. Zvaifler NJ (1973) The immunopathology of joint inflammation in theumatoid arthritis. Adv Immunol 16:265–336

    Google Scholar 

  10. Steffen C (1970) Consideration of pathogenesis of rheumatoid arthritis as collagen autoimmunity. Z Immunitätsforsch Immunobiol 139:219–227

    Google Scholar 

  11. Johnson PM, Faulk WP (1976) Rheumatoid factor: Its nature, specificity, and production in rheumatoid arthritis. Clin Immunol Immunopathol 7:414–430

    Google Scholar 

  12. Notman DD, Kurata N, Tan EM (1975) Profiles of antinuclear antibodies in systemic rheumatic diseases. Ann Int Med 83:464–469

    Google Scholar 

  13. Menzel J, Steffen C, Kolarz G, Scherak O, Smolen JS (1978) Demonstration of anticollagen antibodies in rheumatoid arthritis synovial fluids by 14C-radioimmunoassay. Arthritis Rheum 21:243–248

    Google Scholar 

  14. Hay FC, Nineham LG, Perumal R, Roitt IM (1979) Intraarticular and circulating immune complexes and antiglobulins (IgG and IgM) in rheumatoid arthritis: correlation with clinical features. Ann Rheum Dis 38:1–7

    Google Scholar 

  15. Weisbart RH, Bluestone R, Goldberg LS (1975) Cellular immunity to autologous IgG in rheumatoid arthritis and rheumatoid like disorders. Clin Exp Immunol 20:409–417

    Google Scholar 

  16. Smolen JS, Menzel EJ, Scherak O, Kojer M, Kolarz G, Steffen C, Mayr WR (1980) Lymphocyte transformation to denatured type I collagen and B lymphocyte alloantigens in rheumatoid arthritis. Arthritis Rheum 23:424–432

    Google Scholar 

  17. Reinertsen JL, Klippel JH, Johnson AH, Steinberg AD, Decker JL, Mann DL (1978) B-lymphocyte alloantigens associated with systematic lupus erythematosus. N Engl J Med 299:515–518

    Google Scholar 

  18. Scherak O, Smolen JS, Mayr WR (1979) Prevalence of HLA DRw2 not increased in systemic lupus erythematosus. N Engl J Med 301:612

    Google Scholar 

  19. Stastny P, Fink CW (1979) Different HLA-D associations in adult and juvenile rheumatoid arthritis. J Clin Invest 63:124–130

    Google Scholar 

  20. Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298:869–871

    Google Scholar 

  21. Scherak O, Smolen JS, Mayr WR (1980) Rheumatoid arthritis and B lymphocyte alloantigen HLA DRw4. J Rheumatol 7:9–12

    Google Scholar 

  22. Abdou NI, Pascual E, Racela LS (1979) Suppressor T cell dysfunction and anti suppressor T cell antibody in active early rheumatoid arthritis. Arthritis Rheum 22:586 (Abstr)

    Google Scholar 

  23. Chattopadhyay C, Chattopadhyay H, Natvig JB, Michaelsen TE, and Mellbye OJ (1979) Lack of suppressor cell activity in rheumatoid synovial lymphocytes. Scand J Immunol 10:309–316

    Google Scholar 

  24. Chattopadhyay C, Chattopadhyay H, Natvig JB, Mellbye OJ (1979) Rheumatoid synovial lymphocytes lack concanavalin-A-activated suppressor cell activity. Scand J Immunol 10:479–486

    Google Scholar 

  25. Jasin HE, Ziff M (1975) Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosus. Arthritis Rheum 18:219–228

    Google Scholar 

  26. Tsoukas KD, Carson DA, Fong S, Pasquali JL, Vaughan JH (1980) Cellular requirements for pokeweed mitogen-induced autoantibody production in rheumatoid arthritis. J Immunol 125:1125–1129

    Google Scholar 

  27. Koopman WJ, Schrohenloher RE (1980) Enhanced in vitro synthesis of IgM rheumatoid factor in rheumatoid arthritis. Arthritis Rheum 23:985–992

    Google Scholar 

  28. Nies KM, Louie JS (1978) Impaired immunoglobulin synthesis by peripheral blood lymphocytes in systemic lupus erythematosus. Arthritis Rheum 21:51–57

    Google Scholar 

  29. Fauci AS, Steinberg AD, Haynes BF, Whalen G (1978) Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol 121:1473–1479

    Google Scholar 

  30. Rodnan GP, McEwen C, Wallace SL (eds) (1973) Diagnostic criteria for rheumatoid arthritis. Primer on the rheumatic diseases. JAMA 224 (Suppl 5):137

    Google Scholar 

  31. Steinbrocker O, Traeger CH, Battermann RC (1949) Therapeutic criteria in rheumatoid arthritis (1. Classification of progression of rheumatoid arthritis). JAMA 140:659–662

    Google Scholar 

  32. Pehamberger H, Smolen JS, Menzel J (1980) Failure to detect C1q binding immune complexes in dermatitis herpetiformis. Arch Dermatol Res 268:101–103

    Google Scholar 

  33. Menzel EJ, Kassl M, Smoler JS, Steffen C (in press) A solid phase radioimmunoassay for the quantitation of antibodies to type I, II, and III. Immunol Lett

  34. Knapp W, Baumgartner G (1978) Monocyte-mediated suppression of human B lymphocyte differentiation in vitro. J Immunol 121:1177–1183

    Google Scholar 

  35. Rice L, Laughter AH, Twomey JJ: Three suppressor systems in human blood that modulate lymphoproliferation. J Immunol 122:991–996

  36. Hallgren HM, Yunis EJ: Suppressor lymphocytes in young and aged humans. J Immunol 118:2004–2009

  37. Antel JP, Weinrich M, Arnason BG (1978) Circulating suppressor cells in man as a function of age. Clin Immunol Immunopathol 9:134–141

    Google Scholar 

  38. Sakane T, Steinberg AD, Green I (1980) Studies of immune functions of patients with systemic lupus eythematosus. V. T cell suppressor function and autologous mixed lymphocyte reaction during active and inactive phases of disease. Arthritis Rheum 23:225–231

    Google Scholar 

  39. Scherak O, Smolen JS, Mayr WR (1980) HLA-DRw3 and systemic lupus erythematosus. Arthritis Rheum 23:954–957

    Google Scholar 

  40. Miller KB, Schwartz RS (1979) Familial abnormalities of suppressor function in systemic lupus erythematosus. N Engl J Med 301:803–809

    Google Scholar 

Download references

Author information

Author notes

  1. J. S. Smolen

    Present address: National Institute of Health, Building 10, Room 8D 19, 20 205, Bethesda, Maryland, USA

  2. G. Lanzer

    Present address: Department of Medicine, University of Graz, A-8036, Graz, Austria

Authors and Affiliations

  1. Second Department of Internal Medicine, Institute of Immunology, and Institute of Blood Group Serology, University of Vienna, A-1090, Vienna, Austria

    J. S. Smolen, G. Lanzer, O. Scherak, E. J. Menzel, W. R. Mayr, C. Steffen & W. Knapp

Authors
  1. J. S. Smolen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Lanzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. Scherak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. J. Menzel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. R. Mayr
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Steffen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. Knapp
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

National Blood Group Reference Laboratory (WHO), National Tissue Ty** Reference Laboratory (Council of Europe

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smolen, J.S., Lanzer, G., Scherak, O. et al. Concanavalin A-induced suppressor cell activity and in vitro immunoglobulin secretion in rheumatoid arthritis: Correlation with clinical and immunological parameters. Rheumatol Int 1, 115–120 (1981). https://doi.org/10.1007/BF00541255

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00541255

Key words

Search

Navigation