Summary
Renal and extrarenal effects of aldosterone antagonists on potassium balance were investigated in guinea pigs.
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1.
Pretreatment with 2×120 μmoles/kg spironolactone orally for 3 days increased the tissue: plasma ratio of potassium in cardiac and skeletal muscle. Plasma potassium was unchanged.
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2.
A single dose of 120 μmoles/kg spironolactone orally increased the urinary output of sodium. The renal excretion and clearance of potassium were unchanged.
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3.
In the isolated heart, perfusion with spironolactone or canrenone induced an uptake of potassium. Canrenoate-K and aldosterone were inactive.
It is concluded that in guinea pigs aldosterone antagonists favour a shift of potassium from the extra- to the intracellular space by a direct effect on cardiac and skeletal muscle.
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References
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Mattern, H.R., Schaumann, W. Extrarenal effects of aldosterone antagonists in guinea pigs. Naunyn-Schmiedeberg's Arch. Pharmacol. 279, 1–8 (1973). https://doi.org/10.1007/BF00502062
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DOI: https://doi.org/10.1007/BF00502062