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Paroxysmal neuronal depolarizations in the rat motor cortex in vivo: intracellular injection of the calcium agonist BAY K 8644

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Summary

Epileptic activity was elicited in the rat's motor cortex by local application of penicillin. At the neuronal level it consisted of typical paroxysmal depolarization shifts. The calcium agonist BAY K 8644 was injected into neurons showing such a discharge pattern. The application of this drug increased amplitude and afterdepolarization of paroxysmal neuronal depolarizations.

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References

  • Ayala GF, Matsumoto H, Gumnit RJ (1970) Excitability changes and inhibitory mechanisms in neocortical neurons during seizures. J Neurophysiol 33: 73–85

    PubMed  CAS  Google Scholar 

  • Bingmann D, Speckmann EJ (1985) Calcium antagonists flunarizine and verapamil depress ictal activity in neurons of hippocampal slices. J Neurol 232: 259

    Google Scholar 

  • Boll W, Lux HD (1985) Action of organic antagonists on neuronal calcium currents. Neurosci Lett 56: 335–339

    Article  PubMed  CAS  Google Scholar 

  • Doerner D, Pacheco MF, Fowler JC, Partridge LD (1982) The role of calcium in pentylenetetrazol-induced bursting. Comp Biochem Physiol 73C: 9–12

    Article  Google Scholar 

  • Ducreux C, Takeuchi H, Chalazonitis N (1972) Depolarisation paroxysmale du soma et decharges axoniques d'un même neurone traite au metrazol (neurones autoactifs d'Helix). C R Acad Sci (Paris) 275: 1907–1909

    CAS  Google Scholar 

  • Elger CE, Speckmann EJ (1983) Penicillin-induced epileptic foci in the motor cortex: vertical inhibition. Electroenceph Clin Neurophysiol 56: 604–622

    Article  PubMed  CAS  Google Scholar 

  • Gutnick MJ, Connors BW, Prince DA (1982) Mechanisms of neocortical epileptogenesis in vitro. J Neurophysiol 48: 1321–1335

    PubMed  CAS  Google Scholar 

  • Kramer RH, Zucker RS (1985) Calcium-dependent inward current in aplysia bursting pace-maker neurones. J Physiol 362: 107–130

    PubMed  CAS  Google Scholar 

  • Lux HD, Heinemann U (1983) Consequences of calcium-electrogenesis for the generation of paroxysmal depolarization shift. In: Speckmann EJ, Elger CE (eds) Epilepsy and motor system. Urban and Schwarzenberg, München, pp 100–119

    Google Scholar 

  • Oloffson S, Ridderheim PA, Sivenius H (1980) Topical application of penicillin into hippocampal in vitro slices: a methodological study using benzyl (14C)penicillin. Acta Physiol Scand 109: 27–36

    Article  Google Scholar 

  • Pockberger H, Rappelsberger P, Petsche H (1986) Calcium antagonists and their effects on generation of interictal spikes: a field potential analysis in the neocortex of the rabbit. In: Speckmann EJ, Schulze H, Walden J (eds) Epilepsy and calcium. Urban and Schwarzenberg, München, pp 357–378

    Google Scholar 

  • Prince DA (1968) The depolarization shift in “epileptic” neurons. Exp Neurol 21: 467–485

    Article  PubMed  CAS  Google Scholar 

  • Spector I (1983) A primer in cell culture for patchologists. In: Sakmann B, Neher E (eds) Single channel recording. Plenum Press, New York London, pp 77–90

    Google Scholar 

  • Swandulla D, Lux HD (1985) Activation of a nonspecific cation conductance by intracellular Ca2+ elevation in bursting pacemaker neurons of Helix pomatia. J Neurophysiol 54: 1430–1443

    PubMed  CAS  Google Scholar 

  • Walden J, Pockberger H, Speckmann EJ, Petsche H (1985a) Calcium current in identified snail neurons: effects of the calcium agonist BAY K 8644 and the calcium antagonist nifedipine. Pflügers Arch 405: R8

    Article  Google Scholar 

  • Walden J, Speckmann EJ, Witte OW(1985b) Suppression of focal epileptiform discharges by intraventricular perfusion of a calcium antagonist. Electroenceph Clin Neurophysiol 61: 299–309

    Article  PubMed  CAS  Google Scholar 

  • Walden J, Speckmann EJ, Dietrich LH (1986a) Enhancement of a calcium dependent unspecific inward current by pentylenetetrazol in identified snail neurons (Helix pomatia). Pflügers Arch 406: R11

    Google Scholar 

  • Walden J, Pockberger H, Witte OW, Speckmann EJ, Petsche H (1986b) Effects of organic calcium antagonists and agonists on invertebrate neurons. In: Speckmann EJ, Schulze H, Walden J (eds) Epilepsy and calcium. Urban and Schwarzenberg, München, pp 257–276

    Google Scholar 

  • Witte OW, Speckmann EJ, Walden J (1986) Motor cortical epileptic foci in vivo: actions of a calcium channel blocker on paroxysmal neuronal depolarizations. Electroenceph Clin-Neurophysiol (in press)

  • Wong RKS, Prince DA (1979) Dendritic mechanisms underlying penicillin-induced epileptiform activity. Science 204: 1228–1231

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Physiologisches Institut der Universität, Robert-Koch-Str. 27a, D-4400, Münster, Federal Republic of Germany

    J. Walden & E. -J. Speckmann

  2. Neurophysiologisches Institut der Universität, Währinger Str. 17, A-1090, Wien, Austria

    H. Pockberger & H. Petsche

Authors
  1. J. Walden
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  2. H. Pockberger
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  3. E. -J. Speckmann
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  4. H. Petsche
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Walden, J., Pockberger, H., Speckmann, E.J. et al. Paroxysmal neuronal depolarizations in the rat motor cortex in vivo: intracellular injection of the calcium agonist BAY K 8644. Exp Brain Res 64, 607–609 (1986). https://doi.org/10.1007/BF00340500

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  • DOI: https://doi.org/10.1007/BF00340500

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