Summary
Petite deletion map** has been carried out for the Oli 2 region of the mitochondrial genome of Saccharomyces cerevisiae to produce a fine structure genetic map. Previously unlocated mit - mutants together with the drug resistant loci Oli 2 and Oss 1 have been ordered between the cytochrome oxidase and apocytochrome b genes.
As a result of this study a series of isogenic p - clones have been isolated spanning the Oli 2 region.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Avner PR, Coen D, Dujon B, Slonimski PP (1973) Mitochondrial genetics. IV. Allelism and map** studies of oligomycin resistant mutants in S. cerevisiae. Mol Gen Genet 125:9–52
Avner PR, Griffiths DE (1973) Studies on energy-linked reactions. Genetic analysis of oligomycin-resistant mutants of Saccharomyces cerevisiae. Eur J Biochem 32:312–321
Bolotin-Fukuhara M, Faye G, Fukuhara H (1977) Temperaturesensitive respiration-deficient mitochondrial mutations: Isolation and genetic map**. Mol Gen Genet 152:295–305
Carignani G, Dujardin G, Slonimski PP (1979) Petite deletion map of the mitochondrial Oxi 3 region in Saccharomyces cerevisiae. Mol Gen Genet 167:301–308
Clavilier L (1976) Mitochondrial genetics. XII. An oligomycinresistant mutant localized at a new mitochondrial locus in Saccharomyces cerevisiae. Genetics 83:227–243
Coruzzi G, Trembath MK, Tzagoloff A (1978) Assembly of the mitochondrial membrane system: Mutations in the pho 2 locus of the mitochondrial genome of Saccharomyces cerevisiae. Eur J Biochem 92:279–287
Darlison MG, Lancashire WE (1980) Genetics of oxidative phosphorylation: Allelism studies of mitochondrial loci in the PHO 1-OLI 2 region of the genome. Mol Gen Genet 180:227–229
Foury F, Tzagoloff A (1976) Localization on mitochondrial DNA of mutations leading to a loss of rutamycin-sensitive adenosine triphosphatase. Eur J Biochem 68:113–119
Hensgens LAM, Grivell LA, Borst P, Bos JL (1979) Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex. Proc Natl Acad Sci 76:1663–1667
Lancashire WE, Griffiths DE (1975a) Studies on energy-linked reactions: Genetic analysis of venturicidin-resistant mutants. Eur J Biochem 51:403–413
Lancashire WE, Griffiths DE (1975b) Studies on energy-linked reactions: Isolation, characterisation and genetic analysis of trialkyltin-resistant mutants of Saccharomyces cerevisiae. Eur J Biochem 51:377–392
Lancashire WE, Mattoon JR (1979a) Genetics of oxidative phosphorylation: Mitochondrial loci determining ossamycin-, venturicidin-and oligomycin-resistance in yeast. Mol Gen Genet 176:255–264
Lancashire WE, Mattoon JR (1979b) Cytoduction: A tool for mitochondrial genetic studies in yeast. Utilization of the nuclear-fusion mutations kar 1-1 for transfer of drug r and mit genomes in Saccharomyces cerevisiae. Mol Gen Genet 170:333–344
Macino G, Tzagoloff A (1979a) Assembly of the mitochondrial membrane system: Partial sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae. Proc Natl Acad Sci 76:131–135
Macino G, Tzagoloff A (1979b) Assembly of the mitochondrial membrane system: The DNA sequence of a mitochondrial AT-Pase gene in Saccharomyces cerevisiae. J Biol Chem 254:4617–4623
Macino G, Tzagoloff A (1980) Assembly of the mitochondrial membrane system: Sequence analysis of a yeast mitochondrial ATPase gene containing the oli-2 and oli-4 loci. Cell 20:507–517
Slonimski PP, Tzagoloff A (1976) Localization in yeast mitochondrial DNA of mutations expressed in a dificiency of cytochrome oxidase and/or coenzyme QH2-cytochrome c reductase. Eur J Biochem 61:27–41
Somlo M, Clavilier L, Krupa M (1977) a phantom ATPase in a mitochondrially encoded mutant of Saccharomyces cerevisiae. Mol Gen Genet 156:289–295
Somlo M, Cosson J, Clavilier L, Krupa M, Laporte I (1982) Identity problems concerning subunits of the membrane factor of the mitochondrial ATPase of Saccharomyces cerevisiae. Eur J Biochem 122:369–374
Tzagoloff A, Meagher P (1972) Assembly of the mitochondrial membrane system. Mitochondrial synthesis of subunit proteins of the rutamycin-sensitive adenosine triphosphatase. J Biol Chem 247:594–603
Tzagoloff A, Foury F, Akai A (1976) Assembly of the mitochondrial membrane system XVIII. Genetic loci on mitochondrial DNA involved in cytochrome b biosynthesis. Mol Gen Genet 149:33–42
Author information
Authors and Affiliations
Additional information
Communicated by F. Kaudewitz
Rights and permissions
About this article
Cite this article
Connerton, I.F., Ray, M.K., Lancashire, W.E. et al. Genetics of oxidative phosphorylation: Petite deletion map** of the Oli 2 region of the mitochondrial genome of Saccharomyces cerevisiae . Molec. Gen. Genet. 193, 149–152 (1984). https://doi.org/10.1007/BF00327428
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00327428