Log in

Linkage of the DNA-segment D7S13 (pB79a) with the cystic fibrosis locus

  • Short Communications
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

A map distance of 2.9 cM between D7S13 (pB79a) and the cystic fibrosis (CF) locus was obtained from the analysis of 13 informative families with a history of CF. This result is based solely on the HindIII restriction fragment length polymorphism (HindIII-RFLP) at D7S13, since the interpretation of the Msp1-RFLP at this locus was found to be unreliable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (France)

Instant access to the full article PDF.

References

  • Beaudet A, Bowcock LA, Buchwald M, Cavalli-Sforza L, Farrall M, King MC, Klinger K, Lalouel JM, Lathrop G, Naylor S, Ott J, Tsui LC, Wainwright B, Watkins P, White R, Williamson R (1986) Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study. Am J Hum Genet 39: 681–693

    Google Scholar 

  • Estivill X, Schmidtke J, Williamson R, Wainwright B (1986) Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13). Hum Genet 74:320–322

    Google Scholar 

  • Lathrop GM, Lalouel J-M (1984) Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet 36:460–465

    Google Scholar 

  • Lathrop GM, Lalouel J-M, Julier C, Ott J (1984) Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81: 3443–3446

    Google Scholar 

  • Schmidtke J, Krawczak M, Schwartz M, Alkan M, Bonduelle M, Bühler E, Chemke M, Darnedde T, Domagk J, Engel W, Frey D, Fryburg K, Halley D, Hundrieser J, Ladanyi L, Libaers I, Lissens W, Mächler M, Malik NJ, Morreau J, Neubauer V, Oostra B, Pape B, Poncin JE, Schinzel A, Simon P, Trefz FK, Tümmler B, Vassart G, Voss R (1987) Linkage relationships and allelic associations of cystic fibrosis locus and four marker loci. Hum Genet 76:337–343

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Böhm, D., Krawczak, M. & Schmidtke, J. Linkage of the DNA-segment D7S13 (pB79a) with the cystic fibrosis locus. Hum Genet 78, 186–187 (1988). https://doi.org/10.1007/BF00278194

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00278194

Keywords

Navigation