Summary
Ribosomal RNA synthesis in a purified system is stimulated by a crude protein fraction prepared from E. coli. The positive effector which is not associated with RNA polymerase, nor is the sigma factor, increases the initiation frequency on a rRNA operon. The additional rRNA synthesis is inhibited by ppGpp to the same extent as the basal one.
The evidence presented points to the existence of a positive control element for rRNA synthesis, which activity depends upon the physiological state of the cell.
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Oostra, B.A., Geert, A. & Gruber, M. Specific stimulation of ribosomal RNA synthesis in E. coli by a protein factor. Molec. Gen. Genet. 177, 291–295 (1980). https://doi.org/10.1007/BF00267441
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DOI: https://doi.org/10.1007/BF00267441