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The effect of Indomethacin on the anterior segment of the eye after paracentesis

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Abstract

The prostaglandin-inhibiting effect of Indomethacin (IN) was studied in rabbits, using paracentesis as a stimulus and rise in aqueous protein and fluorescein concentration after intravenous fluorescein injection as parameters. In eyes pre-treated with IN eye-drops the rise in fluorescein and protein concentration in the secondary aqueous was less than in the control eyes; the rise in the control eyes was less than in the eyes of rabbits not treated with IN. There was a good correlation between the rise in protein and the rise in fluorescein concentration in the secondary aqueous.

The four different 0.5% IN suspensions used showed different PG-inhibiting activity, attributed to the difference in physicochemical composition.

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Author notes

  1. J. A. Oosterhuis, J. L. Van Delft & M. Swart-Van Den Berg

    Present address: Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands

  2. N. J. Van Haeringen & E. Glasius

    Present address: Netherlands Ophthalmic Research Institute Wilhelmina Gasthuis, Amsterdam, The Netherlands

Authors and Affiliations

  1. Leiden/Amsterdam, The Netherlands

    J. A. Oosterhuis, N. J. Van Haeringen, E. Glasius, J. L. Van Delft & M. Swart-Van Den Berg

Authors
  1. J. A. Oosterhuis
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  2. N. J. Van Haeringen
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  3. E. Glasius
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  4. J. L. Van Delft
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  5. M. Swart-Van Den Berg
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Oosterhuis, J.A., Van Haeringen, N.J., Glasius, E. et al. The effect of Indomethacin on the anterior segment of the eye after paracentesis. Doc Ophthalmol 50, 303–313 (1981). https://doi.org/10.1007/BF00158014

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  • DOI: https://doi.org/10.1007/BF00158014

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