Abstract
Immobilized papain catalyzed the coupling of N,N′-diBoc-cystine with various amino acid esters in ethyl acetate to produce unsymmetric cystine peptides.
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Adang, A. E. P.; Duindam, A. J. G.; Brussee, J.; Mulder, G. J. and Gen, A. V. D., (1988a). Biochem. J., 255, 715–720.
Adang, A. E. P.; Brussee, J.; Meyer, D. J.; Coles, B.; Gen, A. V. D. and Mulder, G. J., (1988b). Biochem. J. 255, 721–724.
Anderson, M. E. and Meister, A., (1983). Proc. Natl. Acad. Sci. USA 80, 707–711.
Chen, S. -T. and Wang K. -T., (1988a). J. Chem. Soc. Chem. Commun. 327-328.
Chen, S. -T. and Wang K. -T., (1988b). J. Org. Chem. 53, 4589–4590.
Goldschmidt, S.; Lautenschlager, W.; Kolb, B. and Zumach, G., (1964). Chem. Ber. 2434-2438.
Houk, J. and Whitesides, G. M., (1987). J. Am. Chem. Soc. 109, 6825–6836.
Marsh, J. P. Jr. and Goodman, L., (1965). J. Org. Chem. 30, 2491–2493.
Milburn, P. J.; Meinwald, Y. C.; Takahashi, S.; Ooi, T. and Scheraga, H. A., (1988). Int. J. Pept. Prot. Res. 31, 311–321.
Ponsati, B.; Ruiz-Gayo, M.; Giralt, E.; Albericio, F. and Andreu, D., (1990). J, Am. Chem. Soc. 112, 5345–5347.
Richardson, J. S., (1981). Adv. Prot. Chem. 34, 167–339.
Ruiz-Gayo, M.; Albericio, F.; Royo, M.; Pedroso, E. and Giralt, E., (1988). Tetrahedron Lett. 29, 3845–3848.
Sheehan, J. C. and Yang, M.; D. -D. H., (1957). J, Am. Chem. Soc. 79, 1158- 1164.
Tai, D. -F.; Fu, S. -L.; Chuang, S. -F. and Tsai, H., (1988). Biotechnol. Lett. 11, 173–176.
Yajima, H.; Fujii, N.; Funakoshi, S.; Watanabe, T.; Murayama, E. and Otaka, A., (1988). Tetrahedron 44, 805–819.
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Tai, DF., Chen, CE., Huang, CC. et al. Papain catalyzed synthesis of unsymmetric cystine peptides. Biotechnol Lett 15, 961–964 (1993). https://doi.org/10.1007/BF00131764
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DOI: https://doi.org/10.1007/BF00131764